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Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease. However, a major limitation of this approach in quiescent adult primary hepatocytes is that nonhomologous en...

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Detalles Bibliográficos
Autores principales:	VanLith, Caitlin J., Guthman, Rebekah M., Nicolas, Clara T., Allen, Kari L., Liu, Yuanhang, Chilton, Jennifer A., Tritz, Zachariah P., Nyberg, Scott L., Kaiser, Robert A., Lillegard, Joseph B., Hickey, Raymond D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442694/ https://www.ncbi.nlm.nih.gov/pubmed/30976745 http://dx.doi.org/10.1002/hep4.1315

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