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From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?

The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (...

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Autores principales: Ullmann, Enrico, Perry, Seth W., Licinio, Julio, Wong, Ma-Li, Dremencov, Eliyahu, Zavjalov, Evgenii L., Shevelev, Oleg B., Khotskin, Nikita V., Koncevaya, Galina V., Khotshkina, Anna S., Moshkin, Mikhail P., Lapshin, Maxim S., Komelkova, Maria V., Feklicheva, Inna V., Tseilikman, Olga B., Cherkasova, Olga P., Bhui, Kamaldeep S., Jones, Edgar, Kirschbaum, Clemens, Bornstein, Stefan R., Tseilikman, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442703/
https://www.ncbi.nlm.nih.gov/pubmed/30967764
http://dx.doi.org/10.3389/fnbeh.2019.00047
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author Ullmann, Enrico
Perry, Seth W.
Licinio, Julio
Wong, Ma-Li
Dremencov, Eliyahu
Zavjalov, Evgenii L.
Shevelev, Oleg B.
Khotskin, Nikita V.
Koncevaya, Galina V.
Khotshkina, Anna S.
Moshkin, Mikhail P.
Lapshin, Maxim S.
Komelkova, Maria V.
Feklicheva, Inna V.
Tseilikman, Olga B.
Cherkasova, Olga P.
Bhui, Kamaldeep S.
Jones, Edgar
Kirschbaum, Clemens
Bornstein, Stefan R.
Tseilikman, Vadim
author_facet Ullmann, Enrico
Perry, Seth W.
Licinio, Julio
Wong, Ma-Li
Dremencov, Eliyahu
Zavjalov, Evgenii L.
Shevelev, Oleg B.
Khotskin, Nikita V.
Koncevaya, Galina V.
Khotshkina, Anna S.
Moshkin, Mikhail P.
Lapshin, Maxim S.
Komelkova, Maria V.
Feklicheva, Inna V.
Tseilikman, Olga B.
Cherkasova, Olga P.
Bhui, Kamaldeep S.
Jones, Edgar
Kirschbaum, Clemens
Bornstein, Stefan R.
Tseilikman, Vadim
author_sort Ullmann, Enrico
collection PubMed
description The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.
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spelling pubmed-64427032019-04-09 From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? Ullmann, Enrico Perry, Seth W. Licinio, Julio Wong, Ma-Li Dremencov, Eliyahu Zavjalov, Evgenii L. Shevelev, Oleg B. Khotskin, Nikita V. Koncevaya, Galina V. Khotshkina, Anna S. Moshkin, Mikhail P. Lapshin, Maxim S. Komelkova, Maria V. Feklicheva, Inna V. Tseilikman, Olga B. Cherkasova, Olga P. Bhui, Kamaldeep S. Jones, Edgar Kirschbaum, Clemens Bornstein, Stefan R. Tseilikman, Vadim Front Behav Neurosci Neuroscience The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed. Frontiers Media S.A. 2019-03-21 /pmc/articles/PMC6442703/ /pubmed/30967764 http://dx.doi.org/10.3389/fnbeh.2019.00047 Text en Copyright © 2019 Ullmann, Perry, Licinio, Wong, Dremencov, Zavjalov, Shevelev, Khotskin, Koncevaya, Khotshkina, Moshkin, Lapshin, Komelkova, Feklicheva, Tseilikman, Cherkasova, Bhui, Jones, Kirschbaum, Bornstein and Tseilikman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ullmann, Enrico
Perry, Seth W.
Licinio, Julio
Wong, Ma-Li
Dremencov, Eliyahu
Zavjalov, Evgenii L.
Shevelev, Oleg B.
Khotskin, Nikita V.
Koncevaya, Galina V.
Khotshkina, Anna S.
Moshkin, Mikhail P.
Lapshin, Maxim S.
Komelkova, Maria V.
Feklicheva, Inna V.
Tseilikman, Olga B.
Cherkasova, Olga P.
Bhui, Kamaldeep S.
Jones, Edgar
Kirschbaum, Clemens
Bornstein, Stefan R.
Tseilikman, Vadim
From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
title From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
title_full From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
title_fullStr From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
title_full_unstemmed From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
title_short From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
title_sort from allostatic load to allostatic state—an endogenous sympathetic strategy to deal with chronic anxiety and stress?
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442703/
https://www.ncbi.nlm.nih.gov/pubmed/30967764
http://dx.doi.org/10.3389/fnbeh.2019.00047
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