Cargando…
From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442703/ https://www.ncbi.nlm.nih.gov/pubmed/30967764 http://dx.doi.org/10.3389/fnbeh.2019.00047 |
_version_ | 1783407744870514688 |
---|---|
author | Ullmann, Enrico Perry, Seth W. Licinio, Julio Wong, Ma-Li Dremencov, Eliyahu Zavjalov, Evgenii L. Shevelev, Oleg B. Khotskin, Nikita V. Koncevaya, Galina V. Khotshkina, Anna S. Moshkin, Mikhail P. Lapshin, Maxim S. Komelkova, Maria V. Feklicheva, Inna V. Tseilikman, Olga B. Cherkasova, Olga P. Bhui, Kamaldeep S. Jones, Edgar Kirschbaum, Clemens Bornstein, Stefan R. Tseilikman, Vadim |
author_facet | Ullmann, Enrico Perry, Seth W. Licinio, Julio Wong, Ma-Li Dremencov, Eliyahu Zavjalov, Evgenii L. Shevelev, Oleg B. Khotskin, Nikita V. Koncevaya, Galina V. Khotshkina, Anna S. Moshkin, Mikhail P. Lapshin, Maxim S. Komelkova, Maria V. Feklicheva, Inna V. Tseilikman, Olga B. Cherkasova, Olga P. Bhui, Kamaldeep S. Jones, Edgar Kirschbaum, Clemens Bornstein, Stefan R. Tseilikman, Vadim |
author_sort | Ullmann, Enrico |
collection | PubMed |
description | The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed. |
format | Online Article Text |
id | pubmed-6442703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64427032019-04-09 From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? Ullmann, Enrico Perry, Seth W. Licinio, Julio Wong, Ma-Li Dremencov, Eliyahu Zavjalov, Evgenii L. Shevelev, Oleg B. Khotskin, Nikita V. Koncevaya, Galina V. Khotshkina, Anna S. Moshkin, Mikhail P. Lapshin, Maxim S. Komelkova, Maria V. Feklicheva, Inna V. Tseilikman, Olga B. Cherkasova, Olga P. Bhui, Kamaldeep S. Jones, Edgar Kirschbaum, Clemens Bornstein, Stefan R. Tseilikman, Vadim Front Behav Neurosci Neuroscience The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed. Frontiers Media S.A. 2019-03-21 /pmc/articles/PMC6442703/ /pubmed/30967764 http://dx.doi.org/10.3389/fnbeh.2019.00047 Text en Copyright © 2019 Ullmann, Perry, Licinio, Wong, Dremencov, Zavjalov, Shevelev, Khotskin, Koncevaya, Khotshkina, Moshkin, Lapshin, Komelkova, Feklicheva, Tseilikman, Cherkasova, Bhui, Jones, Kirschbaum, Bornstein and Tseilikman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ullmann, Enrico Perry, Seth W. Licinio, Julio Wong, Ma-Li Dremencov, Eliyahu Zavjalov, Evgenii L. Shevelev, Oleg B. Khotskin, Nikita V. Koncevaya, Galina V. Khotshkina, Anna S. Moshkin, Mikhail P. Lapshin, Maxim S. Komelkova, Maria V. Feklicheva, Inna V. Tseilikman, Olga B. Cherkasova, Olga P. Bhui, Kamaldeep S. Jones, Edgar Kirschbaum, Clemens Bornstein, Stefan R. Tseilikman, Vadim From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
title | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
title_full | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
title_fullStr | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
title_full_unstemmed | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
title_short | From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? |
title_sort | from allostatic load to allostatic state—an endogenous sympathetic strategy to deal with chronic anxiety and stress? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442703/ https://www.ncbi.nlm.nih.gov/pubmed/30967764 http://dx.doi.org/10.3389/fnbeh.2019.00047 |
work_keys_str_mv | AT ullmannenrico fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT perrysethw fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT liciniojulio fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT wongmali fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT dremencoveliyahu fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT zavjalovevgeniil fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT shevelevolegb fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT khotskinnikitav fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT koncevayagalinav fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT khotshkinaannas fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT moshkinmikhailp fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT lapshinmaxims fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT komelkovamariav fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT feklichevainnav fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT tseilikmanolgab fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT cherkasovaolgap fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT bhuikamaldeeps fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT jonesedgar fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT kirschbaumclemens fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT bornsteinstefanr fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress AT tseilikmanvadim fromallostaticloadtoallostaticstateanendogenoussympatheticstrategytodealwithchronicanxietyandstress |