Deep targeted sequencing of TP53 in chronic lymphocytic leukemia: clinical impact at diagnosis and at time of treatment

In chronic lymphocytic leukemia, TP53 mutations and deletion of chromosome 17p are well-characterized biomarkers associated with poor progression-free and overall survival following chemoimmunotherapy. Patients harboring low burden TP53 mutations with variant allele frequencies of 0.3-15% have been...

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Detalles Bibliográficos
Autores principales: Brieghel, Christian, Kinalis, Savvas, Yde, Christina W., Schmidt, Ane Y., Jønson, Lars, Andersen, Michael A., da Cunha-Bang, Caspar, Pedersen, Lone B., Geisler, Christian H., Nielsen, Finn C., Niemann, Carsten U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442964/
https://www.ncbi.nlm.nih.gov/pubmed/30514802
http://dx.doi.org/10.3324/haematol.2018.195818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442964/
https://www.ncbi.nlm.nih.gov/pubmed/30514802
http://dx.doi.org/10.3324/haematol.2018.195818

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