The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14

The β-3 sympathomimetic agonist BRL37344 restored nestin-positive cells within the stem cell niche, and thereby normalized blood counts and improved myelofibrosis in a mouse model of JAK2-V617F-positive myeloproliferative neoplasms. We therefore tested the effectiveness of mirabegron, a β-3 sympatho...

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Detalles Bibliográficos
Autores principales: Drexler, Beatrice, Passweg, Jakob R., Tzankov, Alexandar, Bigler, Martin, Theocharides, Alexandre PA, Cantoni, Nathan, Keller, Peter, Stussi, Georg, Ruefer, Axel, Benz, Rudolf, Favre, Geneviève, Lundberg, Pontus, Nienhold, Ronny, Fuhrer, Andrea, Biaggi, Christine, Manz, Markus G., Bargetzi, Mario, Mendez-Ferrer, Simon, Skoda, Radek C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442970/
https://www.ncbi.nlm.nih.gov/pubmed/30409796
http://dx.doi.org/10.3324/haematol.2018.200014

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