Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients

BACKGROUND: Genetic factors play a substantial role in breast cancer etiology. Genes encoding proteins that have key functions in the DNA damage response, such as p53 and its inhibitors MDM2 and MDMX, are most likely candidates to harbor allelic variants that influence breast cancer susceptibility....

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Detalles Bibliográficos
Autores principales: Bauer, Marcus, Kantelhardt, Eva Johanna, Stiewe, Thorsten, Nist, Andrea, Mernberger, Marco, Politt, Katharina, Hanf, Volker, Lantzsch, Tilmann, Uleer, Christoph, Peschel, Susanne, John, Jutta, Buchmann, Jörg, Weigert, Edith, Bürrig, Karl-Friedrich, Wickenhauser, Claudia, Thomssen, Christoph, Bartel, Frank, Vetter, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443004/
https://www.ncbi.nlm.nih.gov/pubmed/30956778
http://dx.doi.org/10.18632/oncotarget.26768

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