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Identification of pathways associated with chemosensitivity through network embedding

Basal gene expression levels have been shown to be predictive of cellular response to cytotoxic treatments. However, such analyses do not fully reveal complex genotype- phenotype relationships, which are partly encoded in highly interconnected molecular networks. Biological pathways provide a comple...

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Detalles Bibliográficos
Autores principales: Wang, Sheng, Huang, Edward, Cairns, Junmei, Peng, Jian, Wang, Liewei, Sinha, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443184/
https://www.ncbi.nlm.nih.gov/pubmed/30893303
http://dx.doi.org/10.1371/journal.pcbi.1006864