Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27(+) quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Here, we describe that deletion of the Cdkn1b gene...

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Detalles Bibliográficos
Autores principales: Ding, Lina, Shunkwiler, Lauren B., Harper, Nicholas W., Zhao, Yang, Hinohara, Kunihiko, Huh, Sung Jin, Ekram, Muhammad B., Guz, Jan, Kern, Michael J., Awgulewitsch, Alexander, Shull, James D., Smits, Bart M. G., Polyak, Kornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443185/
https://www.ncbi.nlm.nih.gov/pubmed/30893315
http://dx.doi.org/10.1371/journal.pgen.1008002

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