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Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons

Cortical hyperexcitability is a hallmark of fragile X syndrome (FXS). In the Fmr1 knockout (KO) mouse model of FXS, cortical hyperexcitability is linked to sensory hypersensitivity and seizure susceptibility. It remains unclear why homeostatic mechanisms fail to prevent such activity. Homeostatic in...

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Detalles Bibliográficos
Autores principales:	Bülow, Pernille, Murphy, T.J., Bassell, Gary J., Wenner, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443253/ https://www.ncbi.nlm.nih.gov/pubmed/30726724 http://dx.doi.org/10.1016/j.celrep.2019.01.035

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