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Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study

OBJECTIVE: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors. METHODS: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients...

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Autores principales: Rech, Tatiana Helena, Custódio, Geisiane, Kroth, Leonardo Viliano, Henrich, Sabrina Frighetto, Filho, Édison Moraes Rodrigues, Crispim, Daisy, Leitão, Cristiane Bauermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Medicina Intensiva Brasileira - AMIB 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443307/
https://www.ncbi.nlm.nih.gov/pubmed/30916235
http://dx.doi.org/10.5935/0103-507X.20190009
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author Rech, Tatiana Helena
Custódio, Geisiane
Kroth, Leonardo Viliano
Henrich, Sabrina Frighetto
Filho, Édison Moraes Rodrigues
Crispim, Daisy
Leitão, Cristiane Bauermann
author_facet Rech, Tatiana Helena
Custódio, Geisiane
Kroth, Leonardo Viliano
Henrich, Sabrina Frighetto
Filho, Édison Moraes Rodrigues
Crispim, Daisy
Leitão, Cristiane Bauermann
author_sort Rech, Tatiana Helena
collection PubMed
description OBJECTIVE: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors. METHODS: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients were divided into two groups: group 1, patients who developed primary graft dysfunction; and group 2, patients who did not develop primary graft dysfunction. Donor plasma levels of TNF, IL-6, IL-1β, and IFN-γ assessed by ELISA were compared between groups. RESULTS: Sixty-nine organs were retrieved, and 48 transplants were performed. Donor plasma cytokine levels did not differ between groups (in pg/mL): TNF, group 1: 10.8 (4.3 - 30.8) versus group 2: 8.7 (4.1 - 33.1), p = 0.63; IL-6, group 1: 1617.8 (106.7 - 5361.7) versus group 2: 922.9 (161.7 - 5361.7), p = 0.56; IL-1β, group 1: 0.1 (0.1 - 126.1) versus group 2: 0.1 (0.1 - 243.6), p = 0.60; and IFN-γ, group 1: 0.03 (0.02 - 0.2) versus group 2: 0.03 (0.02 - 0.1), p = 0.93). Similar findings were obtained when kidney transplants were analyzed separately. CONCLUSION: In this sample of transplant recipients, deceased donor plasma cytokines TNF, IL-6, IL-1β, and IFN-γ were not associated with the development of primary graft dysfunction.
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spelling pubmed-64433072019-04-04 Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study Rech, Tatiana Helena Custódio, Geisiane Kroth, Leonardo Viliano Henrich, Sabrina Frighetto Filho, Édison Moraes Rodrigues Crispim, Daisy Leitão, Cristiane Bauermann Rev Bras Ter Intensiva Original Articles OBJECTIVE: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors. METHODS: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients were divided into two groups: group 1, patients who developed primary graft dysfunction; and group 2, patients who did not develop primary graft dysfunction. Donor plasma levels of TNF, IL-6, IL-1β, and IFN-γ assessed by ELISA were compared between groups. RESULTS: Sixty-nine organs were retrieved, and 48 transplants were performed. Donor plasma cytokine levels did not differ between groups (in pg/mL): TNF, group 1: 10.8 (4.3 - 30.8) versus group 2: 8.7 (4.1 - 33.1), p = 0.63; IL-6, group 1: 1617.8 (106.7 - 5361.7) versus group 2: 922.9 (161.7 - 5361.7), p = 0.56; IL-1β, group 1: 0.1 (0.1 - 126.1) versus group 2: 0.1 (0.1 - 243.6), p = 0.60; and IFN-γ, group 1: 0.03 (0.02 - 0.2) versus group 2: 0.03 (0.02 - 0.1), p = 0.93). Similar findings were obtained when kidney transplants were analyzed separately. CONCLUSION: In this sample of transplant recipients, deceased donor plasma cytokines TNF, IL-6, IL-1β, and IFN-γ were not associated with the development of primary graft dysfunction. Associação de Medicina Intensiva Brasileira - AMIB 2019 /pmc/articles/PMC6443307/ /pubmed/30916235 http://dx.doi.org/10.5935/0103-507X.20190009 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Rech, Tatiana Helena
Custódio, Geisiane
Kroth, Leonardo Viliano
Henrich, Sabrina Frighetto
Filho, Édison Moraes Rodrigues
Crispim, Daisy
Leitão, Cristiane Bauermann
Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
title Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
title_full Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
title_fullStr Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
title_full_unstemmed Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
title_short Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
title_sort brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443307/
https://www.ncbi.nlm.nih.gov/pubmed/30916235
http://dx.doi.org/10.5935/0103-507X.20190009
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