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Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study
OBJECTIVE: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors. METHODS: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Medicina Intensiva Brasileira -
AMIB
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443307/ https://www.ncbi.nlm.nih.gov/pubmed/30916235 http://dx.doi.org/10.5935/0103-507X.20190009 |
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author | Rech, Tatiana Helena Custódio, Geisiane Kroth, Leonardo Viliano Henrich, Sabrina Frighetto Filho, Édison Moraes Rodrigues Crispim, Daisy Leitão, Cristiane Bauermann |
author_facet | Rech, Tatiana Helena Custódio, Geisiane Kroth, Leonardo Viliano Henrich, Sabrina Frighetto Filho, Édison Moraes Rodrigues Crispim, Daisy Leitão, Cristiane Bauermann |
author_sort | Rech, Tatiana Helena |
collection | PubMed |
description | OBJECTIVE: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors. METHODS: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients were divided into two groups: group 1, patients who developed primary graft dysfunction; and group 2, patients who did not develop primary graft dysfunction. Donor plasma levels of TNF, IL-6, IL-1β, and IFN-γ assessed by ELISA were compared between groups. RESULTS: Sixty-nine organs were retrieved, and 48 transplants were performed. Donor plasma cytokine levels did not differ between groups (in pg/mL): TNF, group 1: 10.8 (4.3 - 30.8) versus group 2: 8.7 (4.1 - 33.1), p = 0.63; IL-6, group 1: 1617.8 (106.7 - 5361.7) versus group 2: 922.9 (161.7 - 5361.7), p = 0.56; IL-1β, group 1: 0.1 (0.1 - 126.1) versus group 2: 0.1 (0.1 - 243.6), p = 0.60; and IFN-γ, group 1: 0.03 (0.02 - 0.2) versus group 2: 0.03 (0.02 - 0.1), p = 0.93). Similar findings were obtained when kidney transplants were analyzed separately. CONCLUSION: In this sample of transplant recipients, deceased donor plasma cytokines TNF, IL-6, IL-1β, and IFN-γ were not associated with the development of primary graft dysfunction. |
format | Online Article Text |
id | pubmed-6443307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Associação de Medicina Intensiva Brasileira -
AMIB |
record_format | MEDLINE/PubMed |
spelling | pubmed-64433072019-04-04 Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study Rech, Tatiana Helena Custódio, Geisiane Kroth, Leonardo Viliano Henrich, Sabrina Frighetto Filho, Édison Moraes Rodrigues Crispim, Daisy Leitão, Cristiane Bauermann Rev Bras Ter Intensiva Original Articles OBJECTIVE: To examine the association between donor plasma cytokine levels and the development of primary graft dysfunction of organs transplanted from deceased donors. METHODS: Seventeen deceased donors and the respective 47 transplant recipients were prospectively included in the study. Recipients were divided into two groups: group 1, patients who developed primary graft dysfunction; and group 2, patients who did not develop primary graft dysfunction. Donor plasma levels of TNF, IL-6, IL-1β, and IFN-γ assessed by ELISA were compared between groups. RESULTS: Sixty-nine organs were retrieved, and 48 transplants were performed. Donor plasma cytokine levels did not differ between groups (in pg/mL): TNF, group 1: 10.8 (4.3 - 30.8) versus group 2: 8.7 (4.1 - 33.1), p = 0.63; IL-6, group 1: 1617.8 (106.7 - 5361.7) versus group 2: 922.9 (161.7 - 5361.7), p = 0.56; IL-1β, group 1: 0.1 (0.1 - 126.1) versus group 2: 0.1 (0.1 - 243.6), p = 0.60; and IFN-γ, group 1: 0.03 (0.02 - 0.2) versus group 2: 0.03 (0.02 - 0.1), p = 0.93). Similar findings were obtained when kidney transplants were analyzed separately. CONCLUSION: In this sample of transplant recipients, deceased donor plasma cytokines TNF, IL-6, IL-1β, and IFN-γ were not associated with the development of primary graft dysfunction. Associação de Medicina Intensiva Brasileira - AMIB 2019 /pmc/articles/PMC6443307/ /pubmed/30916235 http://dx.doi.org/10.5935/0103-507X.20190009 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Rech, Tatiana Helena Custódio, Geisiane Kroth, Leonardo Viliano Henrich, Sabrina Frighetto Filho, Édison Moraes Rodrigues Crispim, Daisy Leitão, Cristiane Bauermann Brain death-induced cytokine release is not associated with primary graft dysfunction: a cohort study |
title | Brain death-induced cytokine release is not associated with primary
graft dysfunction: a cohort study |
title_full | Brain death-induced cytokine release is not associated with primary
graft dysfunction: a cohort study |
title_fullStr | Brain death-induced cytokine release is not associated with primary
graft dysfunction: a cohort study |
title_full_unstemmed | Brain death-induced cytokine release is not associated with primary
graft dysfunction: a cohort study |
title_short | Brain death-induced cytokine release is not associated with primary
graft dysfunction: a cohort study |
title_sort | brain death-induced cytokine release is not associated with primary
graft dysfunction: a cohort study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443307/ https://www.ncbi.nlm.nih.gov/pubmed/30916235 http://dx.doi.org/10.5935/0103-507X.20190009 |
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