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Regulation of post-translational modification in breast cancer treatment
The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modifi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Biochemistry and Molecular Biology
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443327/ https://www.ncbi.nlm.nih.gov/pubmed/30638182 http://dx.doi.org/10.5483/BMBRep.2019.52.2.017 |
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author | Heo, Kyung-Sun |
author_facet | Heo, Kyung-Sun |
author_sort | Heo, Kyung-Sun |
collection | PubMed |
description | The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment. |
format | Online Article Text |
id | pubmed-6443327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-64433272019-04-15 Regulation of post-translational modification in breast cancer treatment Heo, Kyung-Sun BMB Rep Invited Mini Review The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment. Korean Society for Biochemistry and Molecular Biology 2019-02 2019-02-28 /pmc/articles/PMC6443327/ /pubmed/30638182 http://dx.doi.org/10.5483/BMBRep.2019.52.2.017 Text en Copyright © 2019 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Mini Review Heo, Kyung-Sun Regulation of post-translational modification in breast cancer treatment |
title | Regulation of post-translational modification in breast cancer treatment |
title_full | Regulation of post-translational modification in breast cancer treatment |
title_fullStr | Regulation of post-translational modification in breast cancer treatment |
title_full_unstemmed | Regulation of post-translational modification in breast cancer treatment |
title_short | Regulation of post-translational modification in breast cancer treatment |
title_sort | regulation of post-translational modification in breast cancer treatment |
topic | Invited Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443327/ https://www.ncbi.nlm.nih.gov/pubmed/30638182 http://dx.doi.org/10.5483/BMBRep.2019.52.2.017 |
work_keys_str_mv | AT heokyungsun regulationofposttranslationalmodificationinbreastcancertreatment |