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Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique

Background  Valve-sparing aortic root replacement (VSARR) is an increasingly popular alternative to traditional aortic root replacement for aortic root aneurysm disease with a normal aortic valve. We evaluated the early and midterm outcomes of VSARR—reimplantation technique (VSARR-RT) done at a sing...

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Autores principales: Cevasco, Marisa, McGurk, Siobhan, Yammine, Maroun, Sharma, Lokesh, Ejiofor, Julius, Norman, Anthony, Singh, Michael N., Shekar, Prem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443388/
https://www.ncbi.nlm.nih.gov/pubmed/30934106
http://dx.doi.org/10.1055/s-0039-1683383
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author Cevasco, Marisa
McGurk, Siobhan
Yammine, Maroun
Sharma, Lokesh
Ejiofor, Julius
Norman, Anthony
Singh, Michael N.
Shekar, Prem
author_facet Cevasco, Marisa
McGurk, Siobhan
Yammine, Maroun
Sharma, Lokesh
Ejiofor, Julius
Norman, Anthony
Singh, Michael N.
Shekar, Prem
author_sort Cevasco, Marisa
collection PubMed
description Background  Valve-sparing aortic root replacement (VSARR) is an increasingly popular alternative to traditional aortic root replacement for aortic root aneurysm disease with a normal aortic valve. We evaluated the early and midterm outcomes of VSARR—reimplantation technique (VSARR-RT) done at a single institution over a decade. Materials and Methods  We performed a retrospective study of all patients who underwent VSARR-RT between January 2004 and July 2014. Results A total of 85 patients underwent VSARR-RT. Median time to latest echocardiographic follow-up was 4 years (range: 15–72 months). Total observation time was 491 patient years. Mean age was 44.6 ± 14.3 years, and 13 (15%) were women. Thirty-nine (46%) patients had a connective tissue disorder and 6 (7%) had a bicuspid aortic valve. Thirty-three (39%) patients underwent concomitant procedures, including coronary artery bypass grafting ( n  = 9, 11%), mitral valve repair ( n  = 8, 9%), and aortic hemi-arch replacement ( n  = 7, 8%). There were no operative deaths or in-house mortality and no postoperative strokes. Kaplan-Meier analysis demonstrated survival of 99% (95% confidence interval [CI]: 97–100%) at 2 years and 98% (95% CI: 97–100%) at 8 years. Freedom from reoperation was 95.8% (95% CI: 91.2–100%) at 8 years. Freedom from endocarditis was 100% at 8 years. At the last echocardiographic follow-up, 95% of patients were free of severe aortic regurgitation (AR) and 82% free of moderate AR. Of the four patients who had severe AR, three underwent reoperations and received prosthetic valves and one is being clinically monitored. Conclusion  This study reports early and midterm outcomes after VSARR-RT at our institution, including those patients who underwent a VSARR-RT procedure combined with other procedures. Further follow-up remains necessary to determine long-term outcomes.
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spelling pubmed-64433882019-04-02 Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique Cevasco, Marisa McGurk, Siobhan Yammine, Maroun Sharma, Lokesh Ejiofor, Julius Norman, Anthony Singh, Michael N. Shekar, Prem Aorta (Stamford) Background  Valve-sparing aortic root replacement (VSARR) is an increasingly popular alternative to traditional aortic root replacement for aortic root aneurysm disease with a normal aortic valve. We evaluated the early and midterm outcomes of VSARR—reimplantation technique (VSARR-RT) done at a single institution over a decade. Materials and Methods  We performed a retrospective study of all patients who underwent VSARR-RT between January 2004 and July 2014. Results A total of 85 patients underwent VSARR-RT. Median time to latest echocardiographic follow-up was 4 years (range: 15–72 months). Total observation time was 491 patient years. Mean age was 44.6 ± 14.3 years, and 13 (15%) were women. Thirty-nine (46%) patients had a connective tissue disorder and 6 (7%) had a bicuspid aortic valve. Thirty-three (39%) patients underwent concomitant procedures, including coronary artery bypass grafting ( n  = 9, 11%), mitral valve repair ( n  = 8, 9%), and aortic hemi-arch replacement ( n  = 7, 8%). There were no operative deaths or in-house mortality and no postoperative strokes. Kaplan-Meier analysis demonstrated survival of 99% (95% confidence interval [CI]: 97–100%) at 2 years and 98% (95% CI: 97–100%) at 8 years. Freedom from reoperation was 95.8% (95% CI: 91.2–100%) at 8 years. Freedom from endocarditis was 100% at 8 years. At the last echocardiographic follow-up, 95% of patients were free of severe aortic regurgitation (AR) and 82% free of moderate AR. Of the four patients who had severe AR, three underwent reoperations and received prosthetic valves and one is being clinically monitored. Conclusion  This study reports early and midterm outcomes after VSARR-RT at our institution, including those patients who underwent a VSARR-RT procedure combined with other procedures. Further follow-up remains necessary to determine long-term outcomes. Thieme Medical Publishers 2019-04-01 /pmc/articles/PMC6443388/ /pubmed/30934106 http://dx.doi.org/10.1055/s-0039-1683383 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cevasco, Marisa
McGurk, Siobhan
Yammine, Maroun
Sharma, Lokesh
Ejiofor, Julius
Norman, Anthony
Singh, Michael N.
Shekar, Prem
Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
title Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
title_full Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
title_fullStr Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
title_full_unstemmed Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
title_short Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
title_sort early and midterm outcomes of valve-sparing aortic root replacement—reimplantation technique
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443388/
https://www.ncbi.nlm.nih.gov/pubmed/30934106
http://dx.doi.org/10.1055/s-0039-1683383
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