How Full-Length FVIII Benefits from Its Heterogeneity – Insights into the Role of the B-Domain

PURPOSE: To explore how the natural heterogeneity of human coagulation factor VIII (FVIII) and the processing of its B-domain specifically modulate protein aggregation. METHODS: Recombinant FVIII (rFVIII) molecular species containing 70% or 20% B-domain, and B-domain-deleted rFVIII (BDD-rFVIII), wer...

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Detalles Bibliográficos
Autores principales: Anzengruber, Julia, Feichtinger, Martin, Bärnthaler, Philipp, Haider, Norbert, Ilas, Josenato, Pruckner, Nina, Benamara, Karima, Scheiflinger, Friedrich, Reipert, Birgit M., Malisauskas, Mantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443606/
https://www.ncbi.nlm.nih.gov/pubmed/30937539
http://dx.doi.org/10.1007/s11095-019-2599-2

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