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miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer

Elevated prostaglandin E(2) (PGE(2)) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE(2) in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE(2)-catabolizing enzyme, 15-hydr...

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Detalles Bibliográficos
Autores principales:	Monteleone, Nicholas J., Moore, Ashleigh E., Iacona, Joseph R., Lutz, Carol S., Dixon, Dan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443653/ https://www.ncbi.nlm.nih.gov/pubmed/30931980 http://dx.doi.org/10.1038/s41598-019-41862-2

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