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Defining Dysbiosis in Patients with Urolithiasis
The prevalence of urinary stone disease (USD) is rapidly rising. However, the factors driving this increase are unknown. Recent microbiome studies suggest that dysbiosis may in part contribute to the increasing prevalence. The objective of the current study was to determine the nature and location o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443657/ https://www.ncbi.nlm.nih.gov/pubmed/30932002 http://dx.doi.org/10.1038/s41598-019-41977-6 |
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author | Zampini, Anna Nguyen, Andrew H. Rose, Emily Monga, Manoj Miller, Aaron W. |
author_facet | Zampini, Anna Nguyen, Andrew H. Rose, Emily Monga, Manoj Miller, Aaron W. |
author_sort | Zampini, Anna |
collection | PubMed |
description | The prevalence of urinary stone disease (USD) is rapidly rising. However, the factors driving this increase are unknown. Recent microbiome studies suggest that dysbiosis may in part contribute to the increasing prevalence. The objective of the current study was to determine the nature and location of dysbiosis associated with USD. We conducted microbiome analysis from the gastrointestinal and urinary tracts, along with a metabolomic analysis of the urinary metabolome, from subjects with an active episode of USD or no history of the disease. Higher rates of antibiotic use among USD patients along with integrated microbiome and metabolomic results support the hypothesis that USD is associated with an antibiotic-driven shift in the microbiome from one that protects against USD to one that promotes the disease. Specifically, our study implicates urinary tract Lactobacillus and Enterobacteriaceae in protective and pathogenic roles for USD, respectively, which conventional, culture-based methods of bacterial analysis from urine and kidney stones would not necessarily detect. Results suggest that antibiotics produce a long-term shift in the microbiome that may increase the risk for USD, with the urinary tract microbiome holding more relevance for USD than the gut microbiome. |
format | Online Article Text |
id | pubmed-6443657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64436572019-04-05 Defining Dysbiosis in Patients with Urolithiasis Zampini, Anna Nguyen, Andrew H. Rose, Emily Monga, Manoj Miller, Aaron W. Sci Rep Article The prevalence of urinary stone disease (USD) is rapidly rising. However, the factors driving this increase are unknown. Recent microbiome studies suggest that dysbiosis may in part contribute to the increasing prevalence. The objective of the current study was to determine the nature and location of dysbiosis associated with USD. We conducted microbiome analysis from the gastrointestinal and urinary tracts, along with a metabolomic analysis of the urinary metabolome, from subjects with an active episode of USD or no history of the disease. Higher rates of antibiotic use among USD patients along with integrated microbiome and metabolomic results support the hypothesis that USD is associated with an antibiotic-driven shift in the microbiome from one that protects against USD to one that promotes the disease. Specifically, our study implicates urinary tract Lactobacillus and Enterobacteriaceae in protective and pathogenic roles for USD, respectively, which conventional, culture-based methods of bacterial analysis from urine and kidney stones would not necessarily detect. Results suggest that antibiotics produce a long-term shift in the microbiome that may increase the risk for USD, with the urinary tract microbiome holding more relevance for USD than the gut microbiome. Nature Publishing Group UK 2019-04-01 /pmc/articles/PMC6443657/ /pubmed/30932002 http://dx.doi.org/10.1038/s41598-019-41977-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zampini, Anna Nguyen, Andrew H. Rose, Emily Monga, Manoj Miller, Aaron W. Defining Dysbiosis in Patients with Urolithiasis |
title | Defining Dysbiosis in Patients with Urolithiasis |
title_full | Defining Dysbiosis in Patients with Urolithiasis |
title_fullStr | Defining Dysbiosis in Patients with Urolithiasis |
title_full_unstemmed | Defining Dysbiosis in Patients with Urolithiasis |
title_short | Defining Dysbiosis in Patients with Urolithiasis |
title_sort | defining dysbiosis in patients with urolithiasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443657/ https://www.ncbi.nlm.nih.gov/pubmed/30932002 http://dx.doi.org/10.1038/s41598-019-41977-6 |
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