CTBP1 depletion on prostate tumors deregulates miRNA/mRNA expression and impairs cancer progression in metabolic syndrome mice

About 20% of prostate cancer (PCa) patients progress to metastatic disease. Metabolic syndrome (MeS) is a pathophysiological disorder that increases PCa risk and aggressiveness. C-terminal binding protein (CTBP1) is a transcriptional corepressor that is activated by high-fat diet (HFD). Previously,...

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Detalles Bibliográficos
Autores principales: Dalton, Guillermo Nicolás, Massillo, Cintia, Scalise, Georgina Daniela, Duca, Rocío, Porretti, Juliana, Farré, Paula Lucia, Gardner, Kevin, Paez, Alejandra, Gueron, Geraldine, De Luca, Paola, De Siervi, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443782/
https://www.ncbi.nlm.nih.gov/pubmed/30931931
http://dx.doi.org/10.1038/s41419-019-1535-z

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