Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

Integrins are components of cell-matrix adhesions, and function as scaffolds for various signal transduction pathways. So far no lipid ligand for integrin has been reported. Here we show that a lipid, oxysterol 25-hydroxycholesterol (25HC), directly binds to α5β1 and αvβ3 integrins to activate integ...

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Detalles Bibliográficos
Autores principales: Pokharel, Swechha M., Shil, Niraj K., GC, Jeevan B., Colburn, Zachary T., Tsai, Su-Yu, Segovia, Jesus A., Chang, Te-Hung, Bandyopadhyay, Smarajit, Natesan, Senthil, Jones, Jonathan C. R., Bose, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443809/
https://www.ncbi.nlm.nih.gov/pubmed/30931941
http://dx.doi.org/10.1038/s41467-019-09453-x

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