Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (RORγt) is the key transcription factor required for Th17 cell differentiation and for production of IL-17 family cytokines by innate and adaptive immune cells. Dysregulated Th17 immune responses have been associated...

Descripción completa

Detalles Bibliográficos
Autores principales: Ecoeur, Florence, Weiss, Jessica, Kaupmann, Klemens, Hintermann, Samuel, Orain, David, Guntermann, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443933/
https://www.ncbi.nlm.nih.gov/pubmed/30972071
http://dx.doi.org/10.3389/fimmu.2019.00577

Ejemplares similares

Ejemplares similares