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Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation

Introduction: As survival of previously considered as lethal congenital heart disease forms is the case in our days, issues regarding quality of life including sport and daily activities emerge. In patients with Fontan circulation, there is no pump to propel blood into the pulmonary arteries since t...

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Autores principales: Stöcker, Fabian, Neidenbach, Rhoia, Fritz, Celina, Oberhoffer, Renate M., Ewert, Peter, Hager, Alfred, Nagdyman, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443956/
https://www.ncbi.nlm.nih.gov/pubmed/30972311
http://dx.doi.org/10.3389/fped.2019.00096
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author Stöcker, Fabian
Neidenbach, Rhoia
Fritz, Celina
Oberhoffer, Renate M.
Ewert, Peter
Hager, Alfred
Nagdyman, Nicole
author_facet Stöcker, Fabian
Neidenbach, Rhoia
Fritz, Celina
Oberhoffer, Renate M.
Ewert, Peter
Hager, Alfred
Nagdyman, Nicole
author_sort Stöcker, Fabian
collection PubMed
description Introduction: As survival of previously considered as lethal congenital heart disease forms is the case in our days, issues regarding quality of life including sport and daily activities emerge. In patients with Fontan circulation, there is no pump to propel blood into the pulmonary arteries since the systemic veins are directly connected to the pulmonary arteries. The complex hemodynamics of Fontan circulation include atrial function, peripheral muscle pump, integrity of the atrioventricular valve, absence of restrictive, or obstructive pulmonary lung function. Therefore, thoracic mechanics are of particular importance within the complex hemodynamics of Fontan circulation. Methods: To understand the physiology of respiratory muscles, the aim of this study was to examine the matching of auxiliary respiratory muscle oxygen delivery and utilization during incremental exercise in young male Fontan patients (n = 22, age = 12.04 ± 2.51) and healthy Controls (n = 10, age = 14.90 ± 2.23). All subjects underwent a cardiopulmonary exercise test (CPET) to exhaustion whereas respiratory muscle oxygenation was measured non-invasively using a near-infrared spectrometer (NIRS). Results: CPET revealed significantly lower peak power output, oxygen uptake and breath activity in Fontan patients. The onset of respiratory muscle deoxygenation was significantly earlier. The matching of local muscle perfusion to oxygen demand was significantly worse in Fontans between 50 and 90% [Formula: see text]. Findings: The results indicate that (a) there is high strain on respiratory muscles during incremental cycling exercise and (b) auxiliary respiratory muscles are worse perfused in patients who underwent a Fontan procedure compared to healthy Controls. This might be indicative of a more general skeletal muscle strain and worse perfusion in Fontan patients rather than a localized-limited to thoracic muscles phenomenon.
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spelling pubmed-64439562019-04-10 Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation Stöcker, Fabian Neidenbach, Rhoia Fritz, Celina Oberhoffer, Renate M. Ewert, Peter Hager, Alfred Nagdyman, Nicole Front Pediatr Pediatrics Introduction: As survival of previously considered as lethal congenital heart disease forms is the case in our days, issues regarding quality of life including sport and daily activities emerge. In patients with Fontan circulation, there is no pump to propel blood into the pulmonary arteries since the systemic veins are directly connected to the pulmonary arteries. The complex hemodynamics of Fontan circulation include atrial function, peripheral muscle pump, integrity of the atrioventricular valve, absence of restrictive, or obstructive pulmonary lung function. Therefore, thoracic mechanics are of particular importance within the complex hemodynamics of Fontan circulation. Methods: To understand the physiology of respiratory muscles, the aim of this study was to examine the matching of auxiliary respiratory muscle oxygen delivery and utilization during incremental exercise in young male Fontan patients (n = 22, age = 12.04 ± 2.51) and healthy Controls (n = 10, age = 14.90 ± 2.23). All subjects underwent a cardiopulmonary exercise test (CPET) to exhaustion whereas respiratory muscle oxygenation was measured non-invasively using a near-infrared spectrometer (NIRS). Results: CPET revealed significantly lower peak power output, oxygen uptake and breath activity in Fontan patients. The onset of respiratory muscle deoxygenation was significantly earlier. The matching of local muscle perfusion to oxygen demand was significantly worse in Fontans between 50 and 90% [Formula: see text]. Findings: The results indicate that (a) there is high strain on respiratory muscles during incremental cycling exercise and (b) auxiliary respiratory muscles are worse perfused in patients who underwent a Fontan procedure compared to healthy Controls. This might be indicative of a more general skeletal muscle strain and worse perfusion in Fontan patients rather than a localized-limited to thoracic muscles phenomenon. Frontiers Media S.A. 2019-03-26 /pmc/articles/PMC6443956/ /pubmed/30972311 http://dx.doi.org/10.3389/fped.2019.00096 Text en Copyright © 2019 Stöcker, Neidenbach, Fritz, Oberhoffer, Ewert, Hager and Nagdyman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Stöcker, Fabian
Neidenbach, Rhoia
Fritz, Celina
Oberhoffer, Renate M.
Ewert, Peter
Hager, Alfred
Nagdyman, Nicole
Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation
title Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation
title_full Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation
title_fullStr Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation
title_full_unstemmed Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation
title_short Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation
title_sort oxygen availability in respiratory muscles during exercise in children following fontan operation
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443956/
https://www.ncbi.nlm.nih.gov/pubmed/30972311
http://dx.doi.org/10.3389/fped.2019.00096
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