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Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis

PURPOSE: Recently, the neutrophil-to-lymphocyte ratio (NLR), an inflammatory response marker, has been reported to be associated with the prognosis in patients with various type of cancer. However, there have been no studies until now that have explored the prognostic role of combined detection of N...

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Autores principales: Kim, Hyunjung, Jung, Hae Il, Kwon, Soon Ha, Bae, Sang Ho, Kim, Hyung Chul, Baek, Moo-Jun, Lee, Moon Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444047/
https://www.ncbi.nlm.nih.gov/pubmed/30941323
http://dx.doi.org/10.4174/astr.2019.96.4.191
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author Kim, Hyunjung
Jung, Hae Il
Kwon, Soon Ha
Bae, Sang Ho
Kim, Hyung Chul
Baek, Moo-Jun
Lee, Moon Soo
author_facet Kim, Hyunjung
Jung, Hae Il
Kwon, Soon Ha
Bae, Sang Ho
Kim, Hyung Chul
Baek, Moo-Jun
Lee, Moon Soo
author_sort Kim, Hyunjung
collection PubMed
description PURPOSE: Recently, the neutrophil-to-lymphocyte ratio (NLR), an inflammatory response marker, has been reported to be associated with the prognosis in patients with various type of cancer. However, there have been no studies until now that have explored the prognostic role of combined detection of NLR and CEA in patients with synchronous liver-limited colorectal metastases (sCRLM). METHODS: Eighty-three patients who histologically diagnosed as sCRLM were selected. Their laboratory and clinical data were collected retrospectively. Using receiver operating characteristic curve analysis, the cutoff value of NLR was calculated based on which patients were assigned to a high NLR (more than 1.94) group and low NLR (less than 1.94) group. A cutoff value of 100 ng/mL for serum CEA level was used in light of the previous literature. RESULTS: CEA level and Poorly differentiated histology of colon cancer was significantly correlated with high NLR (P = 0.005 and P = 0.048, respectively). The multivariate analysis identified the high NLR as independent prognostic factors for OS and DFS in all patients (P = 0.010 and P = 0.006, respectively). Patients with both low levels of NLR and CEA had a significantly longer OS and DFS (P = 0.026 and P = 0.009, respectively). CONCLUSION: In conclusion, elevated preoperative NLR is strongly correlated with both survival and recurrence in patients who have been diagnosed with resectable sCRLM. The combination of NLR and CEA level could be a more powerful prognostic marker than NLR alone.
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spelling pubmed-64440472019-04-02 Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis Kim, Hyunjung Jung, Hae Il Kwon, Soon Ha Bae, Sang Ho Kim, Hyung Chul Baek, Moo-Jun Lee, Moon Soo Ann Surg Treat Res Original Article PURPOSE: Recently, the neutrophil-to-lymphocyte ratio (NLR), an inflammatory response marker, has been reported to be associated with the prognosis in patients with various type of cancer. However, there have been no studies until now that have explored the prognostic role of combined detection of NLR and CEA in patients with synchronous liver-limited colorectal metastases (sCRLM). METHODS: Eighty-three patients who histologically diagnosed as sCRLM were selected. Their laboratory and clinical data were collected retrospectively. Using receiver operating characteristic curve analysis, the cutoff value of NLR was calculated based on which patients were assigned to a high NLR (more than 1.94) group and low NLR (less than 1.94) group. A cutoff value of 100 ng/mL for serum CEA level was used in light of the previous literature. RESULTS: CEA level and Poorly differentiated histology of colon cancer was significantly correlated with high NLR (P = 0.005 and P = 0.048, respectively). The multivariate analysis identified the high NLR as independent prognostic factors for OS and DFS in all patients (P = 0.010 and P = 0.006, respectively). Patients with both low levels of NLR and CEA had a significantly longer OS and DFS (P = 0.026 and P = 0.009, respectively). CONCLUSION: In conclusion, elevated preoperative NLR is strongly correlated with both survival and recurrence in patients who have been diagnosed with resectable sCRLM. The combination of NLR and CEA level could be a more powerful prognostic marker than NLR alone. The Korean Surgical Society 2019-04 2019-03-28 /pmc/articles/PMC6444047/ /pubmed/30941323 http://dx.doi.org/10.4174/astr.2019.96.4.191 Text en Copyright © 2019, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyunjung
Jung, Hae Il
Kwon, Soon Ha
Bae, Sang Ho
Kim, Hyung Chul
Baek, Moo-Jun
Lee, Moon Soo
Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
title Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
title_full Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
title_fullStr Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
title_full_unstemmed Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
title_short Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
title_sort preoperative neutrophil-lymphocyte ratio and cea is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444047/
https://www.ncbi.nlm.nih.gov/pubmed/30941323
http://dx.doi.org/10.4174/astr.2019.96.4.191
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