A Computational Model of Tumor Growth and Anakoinosis

Anakoinosis is a new cancer treatment paradigm that posits a key role for communicative reprogramming within tumor systems. To date no mathematical or computational models of anakoinosis have been developed. Here we outline the NEATG_A system, a first computational model of communicative reprogrammi...

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Detalles Bibliográficos
Autores principales: Pantziarka, Pan, Ghibelli, Lina, Reichle, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444062/
https://www.ncbi.nlm.nih.gov/pubmed/30971926
http://dx.doi.org/10.3389/fphar.2019.00287
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author Pantziarka, Pan
Ghibelli, Lina
Reichle, Albrecht
author_facet Pantziarka, Pan
Ghibelli, Lina
Reichle, Albrecht
author_sort Pantziarka, Pan
collection PubMed
description Anakoinosis is a new cancer treatment paradigm that posits a key role for communicative reprogramming within tumor systems. To date no mathematical or computational models of anakoinosis have been developed. Here we outline the NEATG_A system, a first computational model of communicative reprogramming. The model recapitulates key features of real tumor systems and responses to both traditional cytotoxic treatments and biomodulatory/anakoinotic treatments. Results are presented and discussed, particularly with respect to the implications for future cancer treatment protocols.
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spelling pubmed-64440622019-04-10 A Computational Model of Tumor Growth and Anakoinosis Pantziarka, Pan Ghibelli, Lina Reichle, Albrecht Front Pharmacol Pharmacology Anakoinosis is a new cancer treatment paradigm that posits a key role for communicative reprogramming within tumor systems. To date no mathematical or computational models of anakoinosis have been developed. Here we outline the NEATG_A system, a first computational model of communicative reprogramming. The model recapitulates key features of real tumor systems and responses to both traditional cytotoxic treatments and biomodulatory/anakoinotic treatments. Results are presented and discussed, particularly with respect to the implications for future cancer treatment protocols. Frontiers Media S.A. 2019-03-26 /pmc/articles/PMC6444062/ /pubmed/30971926 http://dx.doi.org/10.3389/fphar.2019.00287 Text en Copyright © 2019 Pantziarka, Ghibelli and Reichle. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Pantziarka, Pan
Ghibelli, Lina
Reichle, Albrecht
A Computational Model of Tumor Growth and Anakoinosis
title A Computational Model of Tumor Growth and Anakoinosis
title_full A Computational Model of Tumor Growth and Anakoinosis
title_fullStr A Computational Model of Tumor Growth and Anakoinosis
title_full_unstemmed A Computational Model of Tumor Growth and Anakoinosis
title_short A Computational Model of Tumor Growth and Anakoinosis
title_sort computational model of tumor growth and anakoinosis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444062/
https://www.ncbi.nlm.nih.gov/pubmed/30971926
http://dx.doi.org/10.3389/fphar.2019.00287
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