KRAS-mutant non-small cell lung cancer: Converging small molecules and immune checkpoint inhibition

KRAS is the most frequent oncogene in non-small cell lung cancer (NSCLC), a molecular subset characterized by historical disappointments in targeted treatment approaches such as farnesyl transferase inhibition, downstream MEK inhibition, and synthetic lethality screens. Unlike other important mutati...

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Detalles Bibliográficos
Autores principales: Adderley, Helen, Blackhall, Fiona H., Lindsay, Colin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444074/
https://www.ncbi.nlm.nih.gov/pubmed/30852159
http://dx.doi.org/10.1016/j.ebiom.2019.02.049

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