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Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444262/ https://www.ncbi.nlm.nih.gov/pubmed/31015829 http://dx.doi.org/10.1155/2019/5157628 |
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author | Zhou, Jiawei He, Zhifen Wu, Yidong Chen, Yiya Chen, Xiaoxin Liang, Yunjie Mao, Yu Yao, Zhimo Lu, Fan Qu, Jia Hess, Robert F. |
author_facet | Zhou, Jiawei He, Zhifen Wu, Yidong Chen, Yiya Chen, Xiaoxin Liang, Yunjie Mao, Yu Yao, Zhimo Lu, Fan Qu, Jia Hess, Robert F. |
author_sort | Zhou, Jiawei |
collection | PubMed |
description | Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. This is a prospective cohort study of 18 amblyopes (10-35 years old; 2 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task; the secondary outcome measures were the best-corrected visual acuity which was measured with a Tumbling E acuity chart and converted to logMAR units and the stereoacuity which was measured with the Random-dot preschool stereogram test. The average binocular gain was 0.11 in terms of the effective contrast ratio (z = −2.344, p = 0.019, 2-tailed related samples Wilcoxon Signed Rank Test). The average acuity gain was 0.13 logMAR equivalent (t(17) = 4.76, p < 0.001, 2-tailed paired samples t-test). The average stereoacuity gain was 339 arc seconds (z = −2.533, p = 0.011). Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long-term gains to binocular balance and that acuity and stereopsis can improve in some subjects. |
format | Online Article Text |
id | pubmed-6444262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64442622019-04-23 Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia Zhou, Jiawei He, Zhifen Wu, Yidong Chen, Yiya Chen, Xiaoxin Liang, Yunjie Mao, Yu Yao, Zhimo Lu, Fan Qu, Jia Hess, Robert F. Neural Plast Research Article Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. This is a prospective cohort study of 18 amblyopes (10-35 years old; 2 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task; the secondary outcome measures were the best-corrected visual acuity which was measured with a Tumbling E acuity chart and converted to logMAR units and the stereoacuity which was measured with the Random-dot preschool stereogram test. The average binocular gain was 0.11 in terms of the effective contrast ratio (z = −2.344, p = 0.019, 2-tailed related samples Wilcoxon Signed Rank Test). The average acuity gain was 0.13 logMAR equivalent (t(17) = 4.76, p < 0.001, 2-tailed paired samples t-test). The average stereoacuity gain was 339 arc seconds (z = −2.533, p = 0.011). Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long-term gains to binocular balance and that acuity and stereopsis can improve in some subjects. Hindawi 2019-03-19 /pmc/articles/PMC6444262/ /pubmed/31015829 http://dx.doi.org/10.1155/2019/5157628 Text en Copyright © 2019 Jiawei Zhou et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Jiawei He, Zhifen Wu, Yidong Chen, Yiya Chen, Xiaoxin Liang, Yunjie Mao, Yu Yao, Zhimo Lu, Fan Qu, Jia Hess, Robert F. Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
title | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
title_full | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
title_fullStr | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
title_full_unstemmed | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
title_short | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
title_sort | inverse occlusion: a binocularly motivated treatment for amblyopia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444262/ https://www.ncbi.nlm.nih.gov/pubmed/31015829 http://dx.doi.org/10.1155/2019/5157628 |
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