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Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia

Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusi...

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Autores principales: Zhou, Jiawei, He, Zhifen, Wu, Yidong, Chen, Yiya, Chen, Xiaoxin, Liang, Yunjie, Mao, Yu, Yao, Zhimo, Lu, Fan, Qu, Jia, Hess, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444262/
https://www.ncbi.nlm.nih.gov/pubmed/31015829
http://dx.doi.org/10.1155/2019/5157628
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author Zhou, Jiawei
He, Zhifen
Wu, Yidong
Chen, Yiya
Chen, Xiaoxin
Liang, Yunjie
Mao, Yu
Yao, Zhimo
Lu, Fan
Qu, Jia
Hess, Robert F.
author_facet Zhou, Jiawei
He, Zhifen
Wu, Yidong
Chen, Yiya
Chen, Xiaoxin
Liang, Yunjie
Mao, Yu
Yao, Zhimo
Lu, Fan
Qu, Jia
Hess, Robert F.
author_sort Zhou, Jiawei
collection PubMed
description Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. This is a prospective cohort study of 18 amblyopes (10-35 years old; 2 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task; the secondary outcome measures were the best-corrected visual acuity which was measured with a Tumbling E acuity chart and converted to logMAR units and the stereoacuity which was measured with the Random-dot preschool stereogram test. The average binocular gain was 0.11 in terms of the effective contrast ratio (z = −2.344, p = 0.019, 2-tailed related samples Wilcoxon Signed Rank Test). The average acuity gain was 0.13 logMAR equivalent (t(17) = 4.76, p < 0.001, 2-tailed paired samples t-test). The average stereoacuity gain was 339 arc seconds (z = −2.533, p = 0.011). Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long-term gains to binocular balance and that acuity and stereopsis can improve in some subjects.
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spelling pubmed-64442622019-04-23 Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia Zhou, Jiawei He, Zhifen Wu, Yidong Chen, Yiya Chen, Xiaoxin Liang, Yunjie Mao, Yu Yao, Zhimo Lu, Fan Qu, Jia Hess, Robert F. Neural Plast Research Article Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. This is a prospective cohort study of 18 amblyopes (10-35 years old; 2 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task; the secondary outcome measures were the best-corrected visual acuity which was measured with a Tumbling E acuity chart and converted to logMAR units and the stereoacuity which was measured with the Random-dot preschool stereogram test. The average binocular gain was 0.11 in terms of the effective contrast ratio (z = −2.344, p = 0.019, 2-tailed related samples Wilcoxon Signed Rank Test). The average acuity gain was 0.13 logMAR equivalent (t(17) = 4.76, p < 0.001, 2-tailed paired samples t-test). The average stereoacuity gain was 339 arc seconds (z = −2.533, p = 0.011). Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long-term gains to binocular balance and that acuity and stereopsis can improve in some subjects. Hindawi 2019-03-19 /pmc/articles/PMC6444262/ /pubmed/31015829 http://dx.doi.org/10.1155/2019/5157628 Text en Copyright © 2019 Jiawei Zhou et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Jiawei
He, Zhifen
Wu, Yidong
Chen, Yiya
Chen, Xiaoxin
Liang, Yunjie
Mao, Yu
Yao, Zhimo
Lu, Fan
Qu, Jia
Hess, Robert F.
Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
title Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
title_full Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
title_fullStr Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
title_full_unstemmed Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
title_short Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
title_sort inverse occlusion: a binocularly motivated treatment for amblyopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444262/
https://www.ncbi.nlm.nih.gov/pubmed/31015829
http://dx.doi.org/10.1155/2019/5157628
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