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Vitamin D receptor polymorphisms and melanoma
Melanoma represents the most aggressive skin cancer, with an unpredictable and often treatment resistant behavior. The etiology of melanoma is multifactorial and includes both environmental and genetic factors. Recent evidence indicates that vitamin D has a role in the development and progression of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444280/ https://www.ncbi.nlm.nih.gov/pubmed/30944611 http://dx.doi.org/10.3892/ol.2018.9733 |
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author | Vasilovici, Alina F. Grigore, Lavinia Elena Ungureanu, Loredana Fechete, Oana Candrea, Elisabeta Trifa, Adrian P. Vișan, Simona Șenilă, Simona Cosgarea, Rodica |
author_facet | Vasilovici, Alina F. Grigore, Lavinia Elena Ungureanu, Loredana Fechete, Oana Candrea, Elisabeta Trifa, Adrian P. Vișan, Simona Șenilă, Simona Cosgarea, Rodica |
author_sort | Vasilovici, Alina F. |
collection | PubMed |
description | Melanoma represents the most aggressive skin cancer, with an unpredictable and often treatment resistant behavior. The etiology of melanoma is multifactorial and includes both environmental and genetic factors. Recent evidence indicates that vitamin D has a role in the development and progression of melanoma. The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Single nucleotide polymorphisms (SNPs) in the vitamin D receptor gene may alter the expression or the function of the VDR protein leading to various diseases, including melanoma. More than 600 SNPs have been identified in the VDR gene, but only a few have been analyzed in relation to melanoma risk: FokI, TaqI, BsmI, ApaI, Cdx2, EcoRV, and BglI. Individual studies carried on small cohorts of patients reported controversial results. In an attempt to clarify the available data in the literature on this subject, we elaborated a systematic review in which we analyzed the relationship between VDR gene polymorphisms and melanoma risk and progression. We concluded that vitamin D pathway is important for the pathogenesis and the progression of cutaneous melanoma, illustrating the gene-environment interactions, but well-designed prospective studies that include data on both genotypes and phenotypes of vitamin D metabolism are essential in order to understand the mechanisms underlying the association between vitamin D and melanoma. |
format | Online Article Text |
id | pubmed-6444280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-64442802019-04-03 Vitamin D receptor polymorphisms and melanoma Vasilovici, Alina F. Grigore, Lavinia Elena Ungureanu, Loredana Fechete, Oana Candrea, Elisabeta Trifa, Adrian P. Vișan, Simona Șenilă, Simona Cosgarea, Rodica Oncol Lett Review Melanoma represents the most aggressive skin cancer, with an unpredictable and often treatment resistant behavior. The etiology of melanoma is multifactorial and includes both environmental and genetic factors. Recent evidence indicates that vitamin D has a role in the development and progression of melanoma. The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Single nucleotide polymorphisms (SNPs) in the vitamin D receptor gene may alter the expression or the function of the VDR protein leading to various diseases, including melanoma. More than 600 SNPs have been identified in the VDR gene, but only a few have been analyzed in relation to melanoma risk: FokI, TaqI, BsmI, ApaI, Cdx2, EcoRV, and BglI. Individual studies carried on small cohorts of patients reported controversial results. In an attempt to clarify the available data in the literature on this subject, we elaborated a systematic review in which we analyzed the relationship between VDR gene polymorphisms and melanoma risk and progression. We concluded that vitamin D pathway is important for the pathogenesis and the progression of cutaneous melanoma, illustrating the gene-environment interactions, but well-designed prospective studies that include data on both genotypes and phenotypes of vitamin D metabolism are essential in order to understand the mechanisms underlying the association between vitamin D and melanoma. D.A. Spandidos 2019-05 2018-11-19 /pmc/articles/PMC6444280/ /pubmed/30944611 http://dx.doi.org/10.3892/ol.2018.9733 Text en Copyright: © Vasilovici et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Vasilovici, Alina F. Grigore, Lavinia Elena Ungureanu, Loredana Fechete, Oana Candrea, Elisabeta Trifa, Adrian P. Vișan, Simona Șenilă, Simona Cosgarea, Rodica Vitamin D receptor polymorphisms and melanoma |
title | Vitamin D receptor polymorphisms and melanoma |
title_full | Vitamin D receptor polymorphisms and melanoma |
title_fullStr | Vitamin D receptor polymorphisms and melanoma |
title_full_unstemmed | Vitamin D receptor polymorphisms and melanoma |
title_short | Vitamin D receptor polymorphisms and melanoma |
title_sort | vitamin d receptor polymorphisms and melanoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444280/ https://www.ncbi.nlm.nih.gov/pubmed/30944611 http://dx.doi.org/10.3892/ol.2018.9733 |
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