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Gfra1 Underexpression Causes Hirschsprung’s Disease and Associated Enterocolitis in Mice

BACKGROUND & AIMS: RET, the receptor for the glial cell line–derived neurotrophic factor (GDNF) family ligands, is the most frequently mutated gene in congenital aganglionic megacolon or Hirschsprung’s disease (HSCR). The leading cause of mortality in HSCR is HSCR-associated enterocolitis (HAEC)...

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Detalles Bibliográficos
Autores principales:	Porokuokka, L. Lauriina, Virtanen, Heikki T., Lindén, Jere, Sidorova, Yulia, Danilova, Tatiana, Lindahl, Maria, Saarma, Mart, Andressoo, Jaan-Olle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444303/ https://www.ncbi.nlm.nih.gov/pubmed/30594740 http://dx.doi.org/10.1016/j.jcmgh.2018.12.007

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