Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report

BACKGROUND: Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30–60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and no androgenic manifestations. We present the first case of a primary mesent...

Descripción completa

Detalles Bibliográficos
Autores principales: Osakabe, Mitsumasa, Sato, Chie, Suzuki, Masamichi, Sugimoto, Ryo, Fujita, Yasuko, Uesugi, Noriyuki, Ishida, Kazuyuki, Itamochi, Hiroaki, Baba, Tsukasa, Sugai, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444432/
https://www.ncbi.nlm.nih.gov/pubmed/30935425
http://dx.doi.org/10.1186/s13000-019-0805-5
Descripción
Sumario:BACKGROUND: Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30–60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and no androgenic manifestations. We present the first case of a primary mesenteric SLCT without DICER1 hotspot mutation. CASE PRESENTATION: An 84-year-old woman presented with a 75-mm mesenteric solid tumor. She presented no androgenic or estrogenic manifestations. She underwent ileocecal resection. Histologically, her mesenteric tumor showed histopathological features that resembled moderately differentiated SLCT. Moreover, DICER1 hotspot mutation was not detected. CONCLUSIONS: We described the first case of heterotopic primary mesenteric SLCT without DICER1 hotspot mutation.

Ejemplares similares