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Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

BACKGROUND: Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs. BCR-ABL-positive cells. METHODS: Gene expression microarrays and RT-qPCR...

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Detalles Bibliográficos
Autores principales:	Schubert, Claudia, Allhoff, Manuel, Tillmann, Stefan, Maié, Tiago, Costa, Ivan G., Lipka, Daniel B., Schemionek, Mirle, Feldberg, Kristina, Baumeister, Julian, Brümmendorf, Tim H., Chatain, Nicolas, Koschmieder, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444528/ https://www.ncbi.nlm.nih.gov/pubmed/30940163 http://dx.doi.org/10.1186/s13045-019-0722-9

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