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Optical coherence elastography of cold cataract in porcine lens

Cataract is one of the most prevalent causes of blindness around the world. Understanding the mechanisms of cataract development and progression is important for clinical diagnosis and treatment. Cold cataract has proven to be a robust model for cataract formation that can be easily controlled in th...

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Autores principales: Zhang, Hongqiu, Wu, Chen, Singh, Manmohan, Nair, Achuth, Aglyamov, Salavat R., Larin, Kirill V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444576/
https://www.ncbi.nlm.nih.gov/pubmed/30864348
http://dx.doi.org/10.1117/1.JBO.24.3.036004
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author Zhang, Hongqiu
Wu, Chen
Singh, Manmohan
Nair, Achuth
Aglyamov, Salavat R.
Larin, Kirill V.
author_facet Zhang, Hongqiu
Wu, Chen
Singh, Manmohan
Nair, Achuth
Aglyamov, Salavat R.
Larin, Kirill V.
author_sort Zhang, Hongqiu
collection PubMed
description Cataract is one of the most prevalent causes of blindness around the world. Understanding the mechanisms of cataract development and progression is important for clinical diagnosis and treatment. Cold cataract has proven to be a robust model for cataract formation that can be easily controlled in the laboratory. There is evidence that the biomechanical properties of the lens can be significantly changed by cataract. Therefore, early detection of cataract, as well as evaluation of therapies, could be guided by characterization of lenticular biomechanical properties. In this work, we utilized optical coherence elastography (OCE) to monitor the changes in biomechanical properties of ex vivo porcine lenses during formation of cold cataract. Elastic waves were induced in the porcine lenses by a focused micro air-pulse while the lenses were cooled, and the elastic wave velocity was translated to Young’s modulus of the lens. The results show an increase in the stiffness of the lens due to formation of the cold cataract (from [Formula: see text] to [Formula: see text]). These results show a relation between lens opacity and stiffness and demonstrate that OCE can assess lenticular biomechanical properties and may be useful for detecting and potentially characterizing cataracts.
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spelling pubmed-64445762020-01-22 Optical coherence elastography of cold cataract in porcine lens Zhang, Hongqiu Wu, Chen Singh, Manmohan Nair, Achuth Aglyamov, Salavat R. Larin, Kirill V. J Biomed Opt Imaging Cataract is one of the most prevalent causes of blindness around the world. Understanding the mechanisms of cataract development and progression is important for clinical diagnosis and treatment. Cold cataract has proven to be a robust model for cataract formation that can be easily controlled in the laboratory. There is evidence that the biomechanical properties of the lens can be significantly changed by cataract. Therefore, early detection of cataract, as well as evaluation of therapies, could be guided by characterization of lenticular biomechanical properties. In this work, we utilized optical coherence elastography (OCE) to monitor the changes in biomechanical properties of ex vivo porcine lenses during formation of cold cataract. Elastic waves were induced in the porcine lenses by a focused micro air-pulse while the lenses were cooled, and the elastic wave velocity was translated to Young’s modulus of the lens. The results show an increase in the stiffness of the lens due to formation of the cold cataract (from [Formula: see text] to [Formula: see text]). These results show a relation between lens opacity and stiffness and demonstrate that OCE can assess lenticular biomechanical properties and may be useful for detecting and potentially characterizing cataracts. Society of Photo-Optical Instrumentation Engineers 2019-03-12 2019-03 /pmc/articles/PMC6444576/ /pubmed/30864348 http://dx.doi.org/10.1117/1.JBO.24.3.036004 Text en © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Imaging
Zhang, Hongqiu
Wu, Chen
Singh, Manmohan
Nair, Achuth
Aglyamov, Salavat R.
Larin, Kirill V.
Optical coherence elastography of cold cataract in porcine lens
title Optical coherence elastography of cold cataract in porcine lens
title_full Optical coherence elastography of cold cataract in porcine lens
title_fullStr Optical coherence elastography of cold cataract in porcine lens
title_full_unstemmed Optical coherence elastography of cold cataract in porcine lens
title_short Optical coherence elastography of cold cataract in porcine lens
title_sort optical coherence elastography of cold cataract in porcine lens
topic Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444576/
https://www.ncbi.nlm.nih.gov/pubmed/30864348
http://dx.doi.org/10.1117/1.JBO.24.3.036004
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