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A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics

Threads, traditionally used in the apparel industry, have recently emerged as a promising material for the creation of tissue constructs and biomedical implants for organ replacement and repair. The wicking property and flexibility of threads also make them promising candidates for the creation of t...

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Autores principales: Mostafalu, Pooria, Akbari, Mohsen, Alberti, Kyle A., Xu, Qiaobing, Khademhosseini, Ali, Sonkusale, Sameer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444711/
https://www.ncbi.nlm.nih.gov/pubmed/31057832
http://dx.doi.org/10.1038/micronano.2016.39
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author Mostafalu, Pooria
Akbari, Mohsen
Alberti, Kyle A.
Xu, Qiaobing
Khademhosseini, Ali
Sonkusale, Sameer R.
author_facet Mostafalu, Pooria
Akbari, Mohsen
Alberti, Kyle A.
Xu, Qiaobing
Khademhosseini, Ali
Sonkusale, Sameer R.
author_sort Mostafalu, Pooria
collection PubMed
description Threads, traditionally used in the apparel industry, have recently emerged as a promising material for the creation of tissue constructs and biomedical implants for organ replacement and repair. The wicking property and flexibility of threads also make them promising candidates for the creation of three-dimensional (3D) microfluidic circuits. In this paper, we report on thread-based microfluidic networks that interface intimately with biological tissues in three dimensions. We have also developed a suite of physical and chemical sensors integrated with microfluidic networks to monitor physiochemical tissue properties, all made from thread, for direct integration with tissues toward the realization of a thread-based diagnostic device (TDD) platform. The physical and chemical sensors are fabricated from nanomaterial-infused conductive threads and are connected to electronic circuitry using thread-based flexible interconnects for readout, signal conditioning, and wireless transmission. To demonstrate the suite of integrated sensors, we utilized TDD platforms to measure strain, as well as gastric and subcutaneous pH in vitro and in vivo.
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spelling pubmed-64447112019-05-03 A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics Mostafalu, Pooria Akbari, Mohsen Alberti, Kyle A. Xu, Qiaobing Khademhosseini, Ali Sonkusale, Sameer R. Microsyst Nanoeng Article Threads, traditionally used in the apparel industry, have recently emerged as a promising material for the creation of tissue constructs and biomedical implants for organ replacement and repair. The wicking property and flexibility of threads also make them promising candidates for the creation of three-dimensional (3D) microfluidic circuits. In this paper, we report on thread-based microfluidic networks that interface intimately with biological tissues in three dimensions. We have also developed a suite of physical and chemical sensors integrated with microfluidic networks to monitor physiochemical tissue properties, all made from thread, for direct integration with tissues toward the realization of a thread-based diagnostic device (TDD) platform. The physical and chemical sensors are fabricated from nanomaterial-infused conductive threads and are connected to electronic circuitry using thread-based flexible interconnects for readout, signal conditioning, and wireless transmission. To demonstrate the suite of integrated sensors, we utilized TDD platforms to measure strain, as well as gastric and subcutaneous pH in vitro and in vivo. Nature Publishing Group 2016-07-18 /pmc/articles/PMC6444711/ /pubmed/31057832 http://dx.doi.org/10.1038/micronano.2016.39 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Mostafalu, Pooria
Akbari, Mohsen
Alberti, Kyle A.
Xu, Qiaobing
Khademhosseini, Ali
Sonkusale, Sameer R.
A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics
title A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics
title_full A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics
title_fullStr A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics
title_full_unstemmed A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics
title_short A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics
title_sort toolkit of thread-based microfluidics, sensors, and electronics for 3d tissue embedding for medical diagnostics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444711/
https://www.ncbi.nlm.nih.gov/pubmed/31057832
http://dx.doi.org/10.1038/micronano.2016.39
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