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Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial

BACKGROUND: The ideal dose of butorphanol for brachial plexus block is not well known. AIMS: This study was carried out to evaluate 1 mg and 2 mg of butorphanol added to 0.375% levobupivacaine, with regard to the duration of analgesia. Our study also sought to assess the onset and duration of sensor...

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Autores principales: Bharathi, B., Praveena, B. Lakshmi, Krishnaveni, K. Neela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444942/
https://www.ncbi.nlm.nih.gov/pubmed/31031501
http://dx.doi.org/10.4103/aer.AER_190_18
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author Bharathi, B.
Praveena, B. Lakshmi
Krishnaveni, K. Neela
author_facet Bharathi, B.
Praveena, B. Lakshmi
Krishnaveni, K. Neela
author_sort Bharathi, B.
collection PubMed
description BACKGROUND: The ideal dose of butorphanol for brachial plexus block is not well known. AIMS: This study was carried out to evaluate 1 mg and 2 mg of butorphanol added to 0.375% levobupivacaine, with regard to the duration of analgesia. Our study also sought to assess the onset and duration of sensorimotor blockade, hemodynamic effects, sedation, and adverse effects. SETTINGS AND DESIGN: This study was a prospective, randomized, double-blinded, and comparative study. METHODS: Eighty adult patients of either sex undergoing upper limb surgeries under supraclavicular brachial plexus block were randomly allocated into two groups. Group LB1 received 29 ml of 0.375% levobupivacaine plus 1 mg of butorphanol diluted in 1 ml of normal saline. Group LB2 received 29 ml of 0.375% levobupivacaine plus 2 mg of butorphanol diluted in 1 ml of normal saline. The onset and duration of sensorimotor blockade, level of sedation, duration of analgesia, and adverse effects were assessed. STATISTICAL ANALYSIS: The data were analyzed with Student's t-test and Chi-square test. RESULTS: The onset of sensory (P = 0.032) and motor block (P = 0.026) was earlier in Group LB2 than in Group LB1. The duration of analgesia was significantly prolonged in Group LB2 (643.55 ± 131.6 vs. 511.73 ± 128.6 min; P = 0.001). The incidence of sedation was observed in more number of patients in Group LB2 (P = 0.01). Furthermore, the incidence of nausea, vomiting, and pruritus were observed in more number of patients in Group LB2 (P < 0.05). CONCLUSION: Higher dose of butorphanol in brachial plexus block hastens the onset and prolongs the duration of sensorimotor blockade and analgesia but is associated with a higher incidence of sedation which requires intense monitoring.
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spelling pubmed-64449422019-04-26 Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial Bharathi, B. Praveena, B. Lakshmi Krishnaveni, K. Neela Anesth Essays Res Original Article BACKGROUND: The ideal dose of butorphanol for brachial plexus block is not well known. AIMS: This study was carried out to evaluate 1 mg and 2 mg of butorphanol added to 0.375% levobupivacaine, with regard to the duration of analgesia. Our study also sought to assess the onset and duration of sensorimotor blockade, hemodynamic effects, sedation, and adverse effects. SETTINGS AND DESIGN: This study was a prospective, randomized, double-blinded, and comparative study. METHODS: Eighty adult patients of either sex undergoing upper limb surgeries under supraclavicular brachial plexus block were randomly allocated into two groups. Group LB1 received 29 ml of 0.375% levobupivacaine plus 1 mg of butorphanol diluted in 1 ml of normal saline. Group LB2 received 29 ml of 0.375% levobupivacaine plus 2 mg of butorphanol diluted in 1 ml of normal saline. The onset and duration of sensorimotor blockade, level of sedation, duration of analgesia, and adverse effects were assessed. STATISTICAL ANALYSIS: The data were analyzed with Student's t-test and Chi-square test. RESULTS: The onset of sensory (P = 0.032) and motor block (P = 0.026) was earlier in Group LB2 than in Group LB1. The duration of analgesia was significantly prolonged in Group LB2 (643.55 ± 131.6 vs. 511.73 ± 128.6 min; P = 0.001). The incidence of sedation was observed in more number of patients in Group LB2 (P = 0.01). Furthermore, the incidence of nausea, vomiting, and pruritus were observed in more number of patients in Group LB2 (P < 0.05). CONCLUSION: Higher dose of butorphanol in brachial plexus block hastens the onset and prolongs the duration of sensorimotor blockade and analgesia but is associated with a higher incidence of sedation which requires intense monitoring. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6444942/ /pubmed/31031501 http://dx.doi.org/10.4103/aer.AER_190_18 Text en Copyright: © 2019 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Bharathi, B.
Praveena, B. Lakshmi
Krishnaveni, K. Neela
Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
title Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
title_full Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
title_fullStr Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
title_full_unstemmed Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
title_short Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
title_sort supraclavicular brachial plexus block: comparison of varying doses of butorphanol combined with levobupivacaine – a double-blind prospective randomized trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444942/
https://www.ncbi.nlm.nih.gov/pubmed/31031501
http://dx.doi.org/10.4103/aer.AER_190_18
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