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Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial
BACKGROUND: The ideal dose of butorphanol for brachial plexus block is not well known. AIMS: This study was carried out to evaluate 1 mg and 2 mg of butorphanol added to 0.375% levobupivacaine, with regard to the duration of analgesia. Our study also sought to assess the onset and duration of sensor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444942/ https://www.ncbi.nlm.nih.gov/pubmed/31031501 http://dx.doi.org/10.4103/aer.AER_190_18 |
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author | Bharathi, B. Praveena, B. Lakshmi Krishnaveni, K. Neela |
author_facet | Bharathi, B. Praveena, B. Lakshmi Krishnaveni, K. Neela |
author_sort | Bharathi, B. |
collection | PubMed |
description | BACKGROUND: The ideal dose of butorphanol for brachial plexus block is not well known. AIMS: This study was carried out to evaluate 1 mg and 2 mg of butorphanol added to 0.375% levobupivacaine, with regard to the duration of analgesia. Our study also sought to assess the onset and duration of sensorimotor blockade, hemodynamic effects, sedation, and adverse effects. SETTINGS AND DESIGN: This study was a prospective, randomized, double-blinded, and comparative study. METHODS: Eighty adult patients of either sex undergoing upper limb surgeries under supraclavicular brachial plexus block were randomly allocated into two groups. Group LB1 received 29 ml of 0.375% levobupivacaine plus 1 mg of butorphanol diluted in 1 ml of normal saline. Group LB2 received 29 ml of 0.375% levobupivacaine plus 2 mg of butorphanol diluted in 1 ml of normal saline. The onset and duration of sensorimotor blockade, level of sedation, duration of analgesia, and adverse effects were assessed. STATISTICAL ANALYSIS: The data were analyzed with Student's t-test and Chi-square test. RESULTS: The onset of sensory (P = 0.032) and motor block (P = 0.026) was earlier in Group LB2 than in Group LB1. The duration of analgesia was significantly prolonged in Group LB2 (643.55 ± 131.6 vs. 511.73 ± 128.6 min; P = 0.001). The incidence of sedation was observed in more number of patients in Group LB2 (P = 0.01). Furthermore, the incidence of nausea, vomiting, and pruritus were observed in more number of patients in Group LB2 (P < 0.05). CONCLUSION: Higher dose of butorphanol in brachial plexus block hastens the onset and prolongs the duration of sensorimotor blockade and analgesia but is associated with a higher incidence of sedation which requires intense monitoring. |
format | Online Article Text |
id | pubmed-6444942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-64449422019-04-26 Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial Bharathi, B. Praveena, B. Lakshmi Krishnaveni, K. Neela Anesth Essays Res Original Article BACKGROUND: The ideal dose of butorphanol for brachial plexus block is not well known. AIMS: This study was carried out to evaluate 1 mg and 2 mg of butorphanol added to 0.375% levobupivacaine, with regard to the duration of analgesia. Our study also sought to assess the onset and duration of sensorimotor blockade, hemodynamic effects, sedation, and adverse effects. SETTINGS AND DESIGN: This study was a prospective, randomized, double-blinded, and comparative study. METHODS: Eighty adult patients of either sex undergoing upper limb surgeries under supraclavicular brachial plexus block were randomly allocated into two groups. Group LB1 received 29 ml of 0.375% levobupivacaine plus 1 mg of butorphanol diluted in 1 ml of normal saline. Group LB2 received 29 ml of 0.375% levobupivacaine plus 2 mg of butorphanol diluted in 1 ml of normal saline. The onset and duration of sensorimotor blockade, level of sedation, duration of analgesia, and adverse effects were assessed. STATISTICAL ANALYSIS: The data were analyzed with Student's t-test and Chi-square test. RESULTS: The onset of sensory (P = 0.032) and motor block (P = 0.026) was earlier in Group LB2 than in Group LB1. The duration of analgesia was significantly prolonged in Group LB2 (643.55 ± 131.6 vs. 511.73 ± 128.6 min; P = 0.001). The incidence of sedation was observed in more number of patients in Group LB2 (P = 0.01). Furthermore, the incidence of nausea, vomiting, and pruritus were observed in more number of patients in Group LB2 (P < 0.05). CONCLUSION: Higher dose of butorphanol in brachial plexus block hastens the onset and prolongs the duration of sensorimotor blockade and analgesia but is associated with a higher incidence of sedation which requires intense monitoring. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6444942/ /pubmed/31031501 http://dx.doi.org/10.4103/aer.AER_190_18 Text en Copyright: © 2019 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Bharathi, B. Praveena, B. Lakshmi Krishnaveni, K. Neela Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial |
title | Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial |
title_full | Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial |
title_fullStr | Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial |
title_full_unstemmed | Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial |
title_short | Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Butorphanol Combined with Levobupivacaine – A Double-Blind Prospective Randomized Trial |
title_sort | supraclavicular brachial plexus block: comparison of varying doses of butorphanol combined with levobupivacaine – a double-blind prospective randomized trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444942/ https://www.ncbi.nlm.nih.gov/pubmed/31031501 http://dx.doi.org/10.4103/aer.AER_190_18 |
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