Soft electrostatic trapping in nanofluidics
Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics. We report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulatio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444982/ https://www.ncbi.nlm.nih.gov/pubmed/31057877 http://dx.doi.org/10.1038/micronano.2017.51 |
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author | Gerspach, Michael A. Mojarad, Nassir Sharma, Deepika Pfohl, Thomas Ekinci, Yasin |
author_facet | Gerspach, Michael A. Mojarad, Nassir Sharma, Deepika Pfohl, Thomas Ekinci, Yasin |
author_sort | Gerspach, Michael A. |
collection | PubMed |
description | Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics. We report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane (PDMS)-based materials. This trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects, called geometry-induced electrostatic (GIE) trapping. With gold nanoparticles as probes, we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps, and compare the results with numerical simulations. When trapping 100 nm particles, we observe potential depths of up to Q≅24 k(B)T that provide stable trapping for many days. Taking advantage of the soft material properties of PDMS, we actively tune the trapping strength and potential depth by elastically reducing the device channel height, which boosts the potential depth up to Q~200 k(B)T, providing practically permanent contact-free trapping. Due to a high-throughput and low-cost fabrication process, ease of use, and excellent trapping performance, our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids. |
format | Online Article Text |
id | pubmed-6444982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-64449822019-05-03 Soft electrostatic trapping in nanofluidics Gerspach, Michael A. Mojarad, Nassir Sharma, Deepika Pfohl, Thomas Ekinci, Yasin Microsyst Nanoeng Article Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical diagnostics. We report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane (PDMS)-based materials. This trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects, called geometry-induced electrostatic (GIE) trapping. With gold nanoparticles as probes, we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps, and compare the results with numerical simulations. When trapping 100 nm particles, we observe potential depths of up to Q≅24 k(B)T that provide stable trapping for many days. Taking advantage of the soft material properties of PDMS, we actively tune the trapping strength and potential depth by elastically reducing the device channel height, which boosts the potential depth up to Q~200 k(B)T, providing practically permanent contact-free trapping. Due to a high-throughput and low-cost fabrication process, ease of use, and excellent trapping performance, our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids. Nature Publishing Group 2017-12-04 /pmc/articles/PMC6444982/ /pubmed/31057877 http://dx.doi.org/10.1038/micronano.2017.51 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Gerspach, Michael A. Mojarad, Nassir Sharma, Deepika Pfohl, Thomas Ekinci, Yasin Soft electrostatic trapping in nanofluidics |
title | Soft electrostatic trapping in nanofluidics |
title_full | Soft electrostatic trapping in nanofluidics |
title_fullStr | Soft electrostatic trapping in nanofluidics |
title_full_unstemmed | Soft electrostatic trapping in nanofluidics |
title_short | Soft electrostatic trapping in nanofluidics |
title_sort | soft electrostatic trapping in nanofluidics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444982/ https://www.ncbi.nlm.nih.gov/pubmed/31057877 http://dx.doi.org/10.1038/micronano.2017.51 |
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