Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(−/−) mice

Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exhibit attenuated activation of the unfolded protein...

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Detalles Bibliográficos
Autores principales: Li, Yan, Tinoco, Roberto, Elmén, Lisa, Segota, Igor, Xian, Yibo, Fujita, Yu, Sahu, Avinash, Zarecki, Raphy, Marie, Kerrie, Feng, Yongmei, Khateb, Ali, Frederick, Dennie T., Ashkenazi, Shiri K., Kim, Hyungsoo, Perez, Eva Guijarro, Day, Chi-Ping, Segura Muñoz, Rafael S., Schmaltz, Robert, Yooseph, Shibu, Tam, Miguel A., Zhang, Tongwu, Avitan-Hersh, Emily, Tzur, Lihi, Roizman, Shoshana, Boyango, Ilanit, Bar-Sela, Gil, Orian, Amir, Kaufman, Randal J., Bosenberg, Marcus, Goding, Colin R., Baaten, Bas, Levesque, Mitchell P., Dummer, Reinhard, Brown, Kevin, Merlino, Glenn, Ruppin, Eytan, Flaherty, Keith, Ramer-Tait, Amanda, Long, Tao, Peterson, Scott N., Bradley, Linda M., Ronai, Ze’ev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445090/
https://www.ncbi.nlm.nih.gov/pubmed/30940817
http://dx.doi.org/10.1038/s41467-019-09525-y

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