Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis

Reactive oxygen species (ROS) are implicated in the aetiology of interstitial lung disease (ILD). We investigated the role of large-scale somatically acquired mutations in mitochondrial DNA (mtDNA) and consecutive respiratory chain dysfunction as a trigger of ROS-formation and lung fibrosis. Mitocho...

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Detalles Bibliográficos
Autores principales: Jaeger, Veronika K., Lebrecht, Dirk, Nicholson, Andrew G., Wells, Athol, Bhayani, Harshil, Gazdhar, Amiq, Tamm, Michael, Venhoff, Nils, Geiser, Thomas, Walker, Ulrich A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445113/
https://www.ncbi.nlm.nih.gov/pubmed/30940853
http://dx.doi.org/10.1038/s41598-019-41933-4

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