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Identification of Allosteric Inhibitors against Active Caspase-6

Caspase-6 is a cysteine protease that plays essential roles in programmed cell death, axonal degeneration, and development. The excess neuronal activity of Caspase-6 is associated with Alzheimer disease neuropathology and age-dependent cognitive impairment. Caspase-6 inhibition is a promising strate...

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Detalles Bibliográficos
Autores principales:	Tubeleviciute-Aydin, Agne, Beautrait, Alexandre, Lynham, Jeffrey, Sharma, Gyanesh, Gorelik, Alexei, Deny, Ludovic J., Soya, Naoto, Lukacs, Gergely L., Nagar, Bhushan, Marinier, Anne, LeBlanc, Andrea C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445123/ https://www.ncbi.nlm.nih.gov/pubmed/30940883 http://dx.doi.org/10.1038/s41598-019-41930-7

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