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Fetal lung C4BPA induces p100 processing in human placenta
The non-canonical NF-κB signaling may be a central integrator of a placental clock that governs the length of human pregnancy. We sought to identify fetal signals that could activate this NF-κB pathway in the placenta, and in turn, contribute to the onset of labor. Proteomics analysis of exosomes pu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445281/ https://www.ncbi.nlm.nih.gov/pubmed/30940885 http://dx.doi.org/10.1038/s41598-019-42078-0 |
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author | Ithier, Mayra Cruz Parobchak, Nataliya Yadava, Stacy Cheng, Jerry Wang, Bingbing Rosen, Todd |
author_facet | Ithier, Mayra Cruz Parobchak, Nataliya Yadava, Stacy Cheng, Jerry Wang, Bingbing Rosen, Todd |
author_sort | Ithier, Mayra Cruz |
collection | PubMed |
description | The non-canonical NF-κB signaling may be a central integrator of a placental clock that governs the length of human pregnancy. We sought to identify fetal signals that could activate this NF-κB pathway in the placenta, and in turn, contribute to the onset of labor. Proteomics analysis of exosomes purified from fetal cord arterial blood revealed a total of 328 proteins, among which 48 were more significantly abundant (p < 0.01) in samples from women who delivered following elective Cesarean-section at term (39 to 40 weeks of estimated gestational age, EGA) compared to those who had elective Cesarean deliveries near term (35 to 36 weeks of EGA). Computational, crystal structural, and gene functional analyses showed that one of these 48 proteins, C4BPA, binds to CD40 of placental villous trophoblast to activate p100 processing to p52, and in turn, pro-labor genes. These results suggest that fetal C4BPA-induced activation of non-canonical NF-κB in human placenta may play a critical role in processes of term or preterm labor. |
format | Online Article Text |
id | pubmed-6445281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64452812019-04-05 Fetal lung C4BPA induces p100 processing in human placenta Ithier, Mayra Cruz Parobchak, Nataliya Yadava, Stacy Cheng, Jerry Wang, Bingbing Rosen, Todd Sci Rep Article The non-canonical NF-κB signaling may be a central integrator of a placental clock that governs the length of human pregnancy. We sought to identify fetal signals that could activate this NF-κB pathway in the placenta, and in turn, contribute to the onset of labor. Proteomics analysis of exosomes purified from fetal cord arterial blood revealed a total of 328 proteins, among which 48 were more significantly abundant (p < 0.01) in samples from women who delivered following elective Cesarean-section at term (39 to 40 weeks of estimated gestational age, EGA) compared to those who had elective Cesarean deliveries near term (35 to 36 weeks of EGA). Computational, crystal structural, and gene functional analyses showed that one of these 48 proteins, C4BPA, binds to CD40 of placental villous trophoblast to activate p100 processing to p52, and in turn, pro-labor genes. These results suggest that fetal C4BPA-induced activation of non-canonical NF-κB in human placenta may play a critical role in processes of term or preterm labor. Nature Publishing Group UK 2019-04-02 /pmc/articles/PMC6445281/ /pubmed/30940885 http://dx.doi.org/10.1038/s41598-019-42078-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ithier, Mayra Cruz Parobchak, Nataliya Yadava, Stacy Cheng, Jerry Wang, Bingbing Rosen, Todd Fetal lung C4BPA induces p100 processing in human placenta |
title | Fetal lung C4BPA induces p100 processing in human placenta |
title_full | Fetal lung C4BPA induces p100 processing in human placenta |
title_fullStr | Fetal lung C4BPA induces p100 processing in human placenta |
title_full_unstemmed | Fetal lung C4BPA induces p100 processing in human placenta |
title_short | Fetal lung C4BPA induces p100 processing in human placenta |
title_sort | fetal lung c4bpa induces p100 processing in human placenta |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445281/ https://www.ncbi.nlm.nih.gov/pubmed/30940885 http://dx.doi.org/10.1038/s41598-019-42078-0 |
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