Population Genetics Based Phylogenetics Under Stabilizing Selection for an Optimal Amino Acid Sequence: A Nested Modeling Approach

We present a new phylogenetic approach, selection on amino acids and codons (SelAC), whose substitution rates are based on a nested model linking protein expression to population genetics. Unlike simpler codon models that assume a single substitution matrix for all sites, our model more realisticall...

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Detalles Bibliográficos
Autores principales: Beaulieu, Jeremy M, O’Meara, Brian C, Zaretzki, Russell, Landerer, Cedric, Chai, Juanjuan, Gilchrist, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445302/
https://www.ncbi.nlm.nih.gov/pubmed/30521036
http://dx.doi.org/10.1093/molbev/msy222

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