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Efficiency measures the conversion of agonist binding energy into receptor conformational change
Receptors alternate between resting↔active conformations that bind agonists with low↔high affinity. Here, we define a new agonist attribute, energy efficiency (η), as the fraction of ligand-binding energy converted into the mechanical work of the activation conformational change. η depends only on t...
Autores principales: | Nayak, Tapan K., Vij, Ridhima, Bruhova, Iva, Shandilya, Jayasha, Auerbach, Anthony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445574/ https://www.ncbi.nlm.nih.gov/pubmed/30635369 http://dx.doi.org/10.1085/jgp.201812215 |
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