The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly pop...

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Autores principales: McBride, Amanda, Houtmann, Sarah, Wilde, Lindsay, Vigil, Carlos, Eischen, Christine M., Kasner, Margaret, Palmisiano, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445951/
https://www.ncbi.nlm.nih.gov/pubmed/30972300
http://dx.doi.org/10.3389/fonc.2019.00192
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author McBride, Amanda
Houtmann, Sarah
Wilde, Lindsay
Vigil, Carlos
Eischen, Christine M.
Kasner, Margaret
Palmisiano, Neil
author_facet McBride, Amanda
Houtmann, Sarah
Wilde, Lindsay
Vigil, Carlos
Eischen, Christine M.
Kasner, Margaret
Palmisiano, Neil
author_sort McBride, Amanda
collection PubMed
description Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.
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spelling pubmed-64459512019-04-10 The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome McBride, Amanda Houtmann, Sarah Wilde, Lindsay Vigil, Carlos Eischen, Christine M. Kasner, Margaret Palmisiano, Neil Front Oncol Oncology Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS. Frontiers Media S.A. 2019-03-27 /pmc/articles/PMC6445951/ /pubmed/30972300 http://dx.doi.org/10.3389/fonc.2019.00192 Text en Copyright © 2019 McBride, Houtmann, Wilde, Vigil, Eischen, Kasner and Palmisiano. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
McBride, Amanda
Houtmann, Sarah
Wilde, Lindsay
Vigil, Carlos
Eischen, Christine M.
Kasner, Margaret
Palmisiano, Neil
The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
title The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
title_full The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
title_fullStr The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
title_full_unstemmed The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
title_short The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
title_sort role of inhibition of apoptosis in acute leukemias and myelodysplastic syndrome
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445951/
https://www.ncbi.nlm.nih.gov/pubmed/30972300
http://dx.doi.org/10.3389/fonc.2019.00192
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