Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling

AChE and BuChE are druggable targets for the discovery of anti-Alzheimer’s disease drugs, while dual-inhibition of these two targets seems to be more effective. In this study, we synthesised a series of novel isoflavone derivatives based on our hit compound G from in silico high-throughput screening...

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Detalles Bibliográficos
Autores principales: Feng, Bo, Li, Xinpeng, Xia, Jie, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446070/
https://www.ncbi.nlm.nih.gov/pubmed/28718678
http://dx.doi.org/10.1080/14756366.2017.1347163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446070/
https://www.ncbi.nlm.nih.gov/pubmed/28718678
http://dx.doi.org/10.1080/14756366.2017.1347163

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