The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and pot...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Shi, Lian-jie, Li, Sheng-guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446120/
https://www.ncbi.nlm.nih.gov/pubmed/31016198
http://dx.doi.org/10.1155/2019/8086257
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author Liu, Wei
Shi, Lian-jie
Li, Sheng-guang
author_facet Liu, Wei
Shi, Lian-jie
Li, Sheng-guang
author_sort Liu, Wei
collection PubMed
description Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.
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spelling pubmed-64461202019-04-23 The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases Liu, Wei Shi, Lian-jie Li, Sheng-guang Biomed Res Int Review Article Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation. Hindawi 2019-03-20 /pmc/articles/PMC6446120/ /pubmed/31016198 http://dx.doi.org/10.1155/2019/8086257 Text en Copyright © 2019 Wei Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Wei
Shi, Lian-jie
Li, Sheng-guang
The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
title The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
title_full The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
title_fullStr The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
title_full_unstemmed The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
title_short The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
title_sort immunomodulatory effect of alpha-lipoic acid in autoimmune diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446120/
https://www.ncbi.nlm.nih.gov/pubmed/31016198
http://dx.doi.org/10.1155/2019/8086257
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