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Sulfasalazine induces mitochondrial dysfunction and renal injury
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446160/ https://www.ncbi.nlm.nih.gov/pubmed/29214868 http://dx.doi.org/10.1080/0886022X.2017.1399908 |
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author | Niknahad, Hossein Heidari, Reza Mohammadzadeh, Roya Ommati, Mohammad Mehdi Khodaei, Forouzan Azarpira, Negar Abdoli, Narges Zarei, Mahdi Asadi, Behnam Rasti, Maryam Shirazi Yeganeh, Babak Taheri, Vahid Saeedi, Arastoo Najibi, Asma |
author_facet | Niknahad, Hossein Heidari, Reza Mohammadzadeh, Roya Ommati, Mohammad Mehdi Khodaei, Forouzan Azarpira, Negar Abdoli, Narges Zarei, Mahdi Asadi, Behnam Rasti, Maryam Shirazi Yeganeh, Babak Taheri, Vahid Saeedi, Arastoo Najibi, Asma |
author_sort | Niknahad, Hossein |
collection | PubMed |
description | Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days. Afterward, kidney mitochondria were isolated and assessed. Sulfasalazine-induced renal injury was biochemically evident by the increase in serum blood urea nitrogen (BUN), gamma-glutamyl transferase (γ-GT), and creatinine (Cr). Histopathological presentations of the kidney in sulfasalazine-treated animals revealed by interstitial inflammation, tubular atrophy, and tissue necrosis. Markers of oxidative stress including an increase in reactive oxygen species (ROS) and lipid peroxidation (LPO), a defect in tissue antioxidant capacity, and glutathione (GSH) depletion were also detected in the kidney of sulfasalazine-treated groups. Decreased mitochondrial succinate dehydrogenase activity (SDA), mitochondrial depolarization, mitochondrial GSH depletion, increase in mitochondrial ROS, LPO, and mitochondrial swelling were also evident in sulfasalazine-treated groups. Current data suggested that oxidative stress and mitochondrial injury might be involved in the mechanism of sulfasalazine-induced renal injury. |
format | Online Article Text |
id | pubmed-6446160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-64461602019-04-09 Sulfasalazine induces mitochondrial dysfunction and renal injury Niknahad, Hossein Heidari, Reza Mohammadzadeh, Roya Ommati, Mohammad Mehdi Khodaei, Forouzan Azarpira, Negar Abdoli, Narges Zarei, Mahdi Asadi, Behnam Rasti, Maryam Shirazi Yeganeh, Babak Taheri, Vahid Saeedi, Arastoo Najibi, Asma Ren Fail Laboratory Study Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days. Afterward, kidney mitochondria were isolated and assessed. Sulfasalazine-induced renal injury was biochemically evident by the increase in serum blood urea nitrogen (BUN), gamma-glutamyl transferase (γ-GT), and creatinine (Cr). Histopathological presentations of the kidney in sulfasalazine-treated animals revealed by interstitial inflammation, tubular atrophy, and tissue necrosis. Markers of oxidative stress including an increase in reactive oxygen species (ROS) and lipid peroxidation (LPO), a defect in tissue antioxidant capacity, and glutathione (GSH) depletion were also detected in the kidney of sulfasalazine-treated groups. Decreased mitochondrial succinate dehydrogenase activity (SDA), mitochondrial depolarization, mitochondrial GSH depletion, increase in mitochondrial ROS, LPO, and mitochondrial swelling were also evident in sulfasalazine-treated groups. Current data suggested that oxidative stress and mitochondrial injury might be involved in the mechanism of sulfasalazine-induced renal injury. Taylor & Francis 2017-12-07 /pmc/articles/PMC6446160/ /pubmed/29214868 http://dx.doi.org/10.1080/0886022X.2017.1399908 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Laboratory Study Niknahad, Hossein Heidari, Reza Mohammadzadeh, Roya Ommati, Mohammad Mehdi Khodaei, Forouzan Azarpira, Negar Abdoli, Narges Zarei, Mahdi Asadi, Behnam Rasti, Maryam Shirazi Yeganeh, Babak Taheri, Vahid Saeedi, Arastoo Najibi, Asma Sulfasalazine induces mitochondrial dysfunction and renal injury |
title | Sulfasalazine induces mitochondrial dysfunction and renal injury |
title_full | Sulfasalazine induces mitochondrial dysfunction and renal injury |
title_fullStr | Sulfasalazine induces mitochondrial dysfunction and renal injury |
title_full_unstemmed | Sulfasalazine induces mitochondrial dysfunction and renal injury |
title_short | Sulfasalazine induces mitochondrial dysfunction and renal injury |
title_sort | sulfasalazine induces mitochondrial dysfunction and renal injury |
topic | Laboratory Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446160/ https://www.ncbi.nlm.nih.gov/pubmed/29214868 http://dx.doi.org/10.1080/0886022X.2017.1399908 |
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