Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

BACKGROUND: Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in mice and inhibiting circulating TGFβ reduced...

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Autores principales: McMillin, Matthew, Grant, Stephanie, Frampton, Gabriel, Petrescu, Anca D., Williams, Elaina, Jefferson, Brandi, Thomas, Alison, Brahmaroutu, Ankita, DeMorrow, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446280/
https://www.ncbi.nlm.nih.gov/pubmed/30940161
http://dx.doi.org/10.1186/s12974-019-1455-y

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