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Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan

OBJECTIVE: To assess the clinical presentation and hematological profile among young (≤ 55 years) and old (> 55 years) chronic lymphocytic leukemia patients in Sudan. RESULT: In the present cross-sectional descriptive study, out of 110 cases studied, among them 31 (28.2%) were young (≤ 55 years)...

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Autores principales: Basabaeen, Ameen Abdulaziz, Abdelgader, Enaam Abdelrhman, Babekir, Ebtihal Ahmed, Eltayeb, Nada Hassan, Altayeb, Osama Ali, Fadul, Eman Abbass, Bahashwan, Othman Saeed, Ibrahim, Ibrahim Khider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446286/
https://www.ncbi.nlm.nih.gov/pubmed/30940190
http://dx.doi.org/10.1186/s13104-019-4239-7
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author Basabaeen, Ameen Abdulaziz
Abdelgader, Enaam Abdelrhman
Babekir, Ebtihal Ahmed
Eltayeb, Nada Hassan
Altayeb, Osama Ali
Fadul, Eman Abbass
Bahashwan, Othman Saeed
Ibrahim, Ibrahim Khider
author_facet Basabaeen, Ameen Abdulaziz
Abdelgader, Enaam Abdelrhman
Babekir, Ebtihal Ahmed
Eltayeb, Nada Hassan
Altayeb, Osama Ali
Fadul, Eman Abbass
Bahashwan, Othman Saeed
Ibrahim, Ibrahim Khider
author_sort Basabaeen, Ameen Abdulaziz
collection PubMed
description OBJECTIVE: To assess the clinical presentation and hematological profile among young (≤ 55 years) and old (> 55 years) chronic lymphocytic leukemia patients in Sudan. RESULT: In the present cross-sectional descriptive study, out of 110 cases studied, among them 31 (28.2%) were young (≤ 55 years) patients with mean age 48 years, and 79 (71.8%) were elder patients (> 55 years) with mean age 66 years, the overall mean age was 62.97 ± 12.06 with range (22–85 years), and 79 (71.8%) were males and 31 (28.2%) were females (M:F = 2.6:1) (P = 0.000). (7.3%) were asymptomatic, 61 (55.5%) presented with nonspecific complains. Generalized lymphadenopathy was seen in 52 (47.27%) with elder predominance (P = 0.03). Splenomegaly, hepatomegaly, thrombocytopenia and anemia were seen in 54 (49.1%), 14 (12.7%), 43 (39.1%) and 38 (34.5%) of patients respectively with male predominance. 54 (49.1%) and 42 (38.18%) of patients presented at Rai high risk and Binet C stages respectively with nearly same age and sex distribution. CLL in Sudan is a disease of elders, same as seen in literature, with high male to female ratio. In general hematological parameters means were noted to be distributed equally according to age and sex groups. Majority of patients were presented with nonspecific symptoms and nearly half of patients presented at late stages as reported in most developing countries. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-019-4239-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-64462862019-04-12 Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan Basabaeen, Ameen Abdulaziz Abdelgader, Enaam Abdelrhman Babekir, Ebtihal Ahmed Eltayeb, Nada Hassan Altayeb, Osama Ali Fadul, Eman Abbass Bahashwan, Othman Saeed Ibrahim, Ibrahim Khider BMC Res Notes Research Note OBJECTIVE: To assess the clinical presentation and hematological profile among young (≤ 55 years) and old (> 55 years) chronic lymphocytic leukemia patients in Sudan. RESULT: In the present cross-sectional descriptive study, out of 110 cases studied, among them 31 (28.2%) were young (≤ 55 years) patients with mean age 48 years, and 79 (71.8%) were elder patients (> 55 years) with mean age 66 years, the overall mean age was 62.97 ± 12.06 with range (22–85 years), and 79 (71.8%) were males and 31 (28.2%) were females (M:F = 2.6:1) (P = 0.000). (7.3%) were asymptomatic, 61 (55.5%) presented with nonspecific complains. Generalized lymphadenopathy was seen in 52 (47.27%) with elder predominance (P = 0.03). Splenomegaly, hepatomegaly, thrombocytopenia and anemia were seen in 54 (49.1%), 14 (12.7%), 43 (39.1%) and 38 (34.5%) of patients respectively with male predominance. 54 (49.1%) and 42 (38.18%) of patients presented at Rai high risk and Binet C stages respectively with nearly same age and sex distribution. CLL in Sudan is a disease of elders, same as seen in literature, with high male to female ratio. In general hematological parameters means were noted to be distributed equally according to age and sex groups. Majority of patients were presented with nonspecific symptoms and nearly half of patients presented at late stages as reported in most developing countries. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-019-4239-7) contains supplementary material, which is available to authorized users. BioMed Central 2019-04-02 /pmc/articles/PMC6446286/ /pubmed/30940190 http://dx.doi.org/10.1186/s13104-019-4239-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Basabaeen, Ameen Abdulaziz
Abdelgader, Enaam Abdelrhman
Babekir, Ebtihal Ahmed
Eltayeb, Nada Hassan
Altayeb, Osama Ali
Fadul, Eman Abbass
Bahashwan, Othman Saeed
Ibrahim, Ibrahim Khider
Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan
title Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan
title_full Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan
title_fullStr Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan
title_full_unstemmed Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan
title_short Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan
title_sort clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in sudan
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446286/
https://www.ncbi.nlm.nih.gov/pubmed/30940190
http://dx.doi.org/10.1186/s13104-019-4239-7
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