Robustness of signal detection in cryo-electron microscopy via a bi-objective-function approach

BACKGROUND: The detection of weak signals and selection of single particles from low-contrast micrographs of frozen hydrated biomolecules by cryo-electron microscopy (cryo-EM) represents a major practical bottleneck in cryo-EM data analysis. Template-based particle picking by an objective function u...

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Detalles Bibliográficos
Autores principales: Wang, Wei Li, Yu, Zhou, Castillo-Menendez, Luis R., Sodroski, Joseph, Mao, Youdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446299/
https://www.ncbi.nlm.nih.gov/pubmed/30943890
http://dx.doi.org/10.1186/s12859-019-2714-8

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