Highly efficient correction of structural mutations of 450 kb KIT locus in kidney cells of Yorkshire pig by CRISPR/Cas9

The white coat colour of Yorkshire and Landrace pig breeds is caused by the dominant white I allele of KIT, associated with 450-kb duplications and a splice mutation (G > A) at the first base in intron 17. To test whether genome editing can be employed to correct this structural mutation, and to...

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Detalles Bibliográficos
Autores principales: Qin, Ke, Liang, Xinyu, Sun, Guanjie, Shi, Xuan, Wang, Min, Liu, Hongbo, Chen, Yaosheng, Liu, Xiaohong, He, Zuyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446502/
https://www.ncbi.nlm.nih.gov/pubmed/31041890
http://dx.doi.org/10.1186/s12860-019-0184-5

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