CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability

The RNA polymerase II (RNAPII) C-terminal domain kinase, CDK12, regulates genome stability, expression of DNA repair genes, and cancer cell resistance to chemotherapy and immunotherapy. In addition to its role in mRNA biosynthesis of DNA repair genes, we show here that CDK12 phosphorylates the mRNA...

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Detalles Bibliográficos
Autores principales: Choi, Seung H., Martinez, Thomas F., Kim, Seongjae, Donaldson, Cynthia, Shokhirev, Maxim N., Saghatelian, Alan, Jones, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446539/
https://www.ncbi.nlm.nih.gov/pubmed/30819820
http://dx.doi.org/10.1101/gad.322339.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446539/
https://www.ncbi.nlm.nih.gov/pubmed/30819820
http://dx.doi.org/10.1101/gad.322339.118

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