Cargando…

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability

The RNA polymerase II (RNAPII) C-terminal domain kinase, CDK12, regulates genome stability, expression of DNA repair genes, and cancer cell resistance to chemotherapy and immunotherapy. In addition to its role in mRNA biosynthesis of DNA repair genes, we show here that CDK12 phosphorylates the mRNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Seung H., Martinez, Thomas F., Kim, Seongjae, Donaldson, Cynthia, Shokhirev, Maxim N., Saghatelian, Alan, Jones, Katherine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446539/ https://www.ncbi.nlm.nih.gov/pubmed/30819820 http://dx.doi.org/10.1101/gad.322339.118

Ejemplares similares

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
por: Tsukumo, Yoshinori, et al.
Publicado: (2016)

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
por: Odle, Richard I., et al.
Publicado: (2020)

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
por: Jia, Jian-Jun, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
por: Murai, Atsuko, et al.
Publicado: (2012)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity
por: Bartley, Christopher M., et al.
Publicado: (2014)

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
por: Antonia, Ricardo J., et al.
Publicado: (2019)

mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1
por: Kaeser-Pebernard, Stéphanie, et al.
Publicado: (2022)

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition
por: Yuan, Hai-Xin, et al.
Publicado: (2015)

mTORc1 activity is necessary and sufficient for phosphorylation of eNOS(S1177)
por: Decker, Brandee, et al.
Publicado: (2018)

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
por: Jewell, Jenna L, et al.
Publicado: (2019)

Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
por: Ren, Qian‐Nan, et al.
Publicado: (2021)

Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis
por: Wang, Guoyan, et al.
Publicado: (2023)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
por: Llanos, Susana, et al.
Publicado: (2016)

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)
por: Rios-Fuller, Tiffany J., et al.
Publicado: (2020)

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
por: He, Chang-Liang, et al.
Publicado: (2016)

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
por: Clemm von Hohenberg, Katharina, et al.
Publicado: (2022)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of Mitochondrial Biogenesis in Erythropoiesis by mTORC1-Mediated Protein Translation
por: Liu, Xin, et al.
Publicado: (2017)

Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis
por: Iezaki, Takashi, et al.
Publicado: (2018)

Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors
por: Harter, Patrick N., et al.
Publicado: (2015)

mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation
por: Alayev, A, et al.
Publicado: (2015)

mTORC1 phosphorylates LARP6 to stimulate type I collagen expression
por: Zhang, Yujie, et al.
Publicado: (2017)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
por: Woodcock, Hannah V., et al.
Publicado: (2019)

AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation
por: Faienza, Fiorella, et al.
Publicado: (2023)

Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice
por: Sun, Rui, et al.
Publicado: (2023)

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors
por: Yoshida, Akihiro, et al.
Publicado: (2019)

CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
por: Yin, Shasha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9biqchim1jn3o4v7ks6a85u0qn