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Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

Caenorhabditis elegans has two histone H3 Lys9 methyltransferases, MET-2 (SETDB1 homolog) and SET-25 (G9a/SUV39H1 related). In worms, we found simple repeat sequences primarily marked by H3K9me2, while transposable elements and silent tissue-specific genes bear H3K9me3. RNA sequencing (RNA-seq) in h...

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Detalles Bibliográficos
Autores principales:	Padeken, Jan, Zeller, Peter, Towbin, Benjamin, Katic, Iskra, Kalck, Veronique, Methot, Stephen P., Gasser, Susan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446544/ https://www.ncbi.nlm.nih.gov/pubmed/30804228 http://dx.doi.org/10.1101/gad.322495.118

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