Cancer Chemotherapy: Redox‐Responsive Dual Drug Delivery Nanosystem Suppresses Cancer Repopulation by Abrogating Doxorubicin‐Promoted Cancer Stemness, Metastasis, and Drug Resistance (Adv. Sci. 7/2019)

Chemotherapy effectiveness is greatly challenged by chemodrugs' intrinsic pathological interactions with tumor cells, which enhance cancer stemness, invasiveness and acquired drug resistance. In article number 1801987, Guobin Wang, Zheng Wang, Lin Wang, and co‐workers construct a redox‐responsi...

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Detalles Bibliográficos
Autores principales: Liu, Jia, Chang, Bingcheng, Li, Qilin, Xu, Luming, Liu, Xingxin, Wang, Guobin, Wang, Zheng, Wang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Inside Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446611/
http://dx.doi.org/10.1002/advs.201970043
Descripción
Sumario:Chemotherapy effectiveness is greatly challenged by chemodrugs' intrinsic pathological interactions with tumor cells, which enhance cancer stemness, invasiveness and acquired drug resistance. In article number 1801987, Guobin Wang, Zheng Wang, Lin Wang, and co‐workers construct a redox‐responsive, celecoxib‐modified nanosystem that efficiently enhances doxorubicin‐based chemotherapy and suppresses cancer repopulation by abrogating doxorubicin‐induced enhancement of cancer stemness, metastasis and drug resistance. [Image: see text]

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