Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not ini...

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Detalles Bibliográficos
Autores principales: Nair, Praful R., Wirtz, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446847/
https://www.ncbi.nlm.nih.gov/pubmed/30872360
http://dx.doi.org/10.1083/jcb.201902035
Descripción
Sumario:Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

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