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Quantitative phosphoproteomics reveals mitotic function of the ATR activator ETAA1

The ATR kinase controls cell cycle transitions and the DNA damage response. ATR activity is regulated through two ATR-activating proteins, ETAA1 and TOPBP1. To examine how each activator contributes to ATR signaling, we used quantitative mass spectrometry to identify changes in protein phosphorylati...

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Detalles Bibliográficos
Autores principales: Bass, Thomas E., Cortez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446857/
https://www.ncbi.nlm.nih.gov/pubmed/30755469
http://dx.doi.org/10.1083/jcb.201810058